Dynamic Pharmacogenetic Models in Anticoagulation Therapy
Dynamic Pharmacogenetic Models in Anticoagulation Therapy
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DOI:
10.1016/j.cll.2008.10.002
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发表时间:
2008-12-01
影响因子:
1.7
通讯作者:
Linder, Mark W.
中科院分区:
文献类型:
--
作者:
Homme, Marjorie Bon;Reynolds, Kristen K.;Linder, Mark W.
This article demonstrates how a dynamic clinical-support tool can guide individualized drug therapy. We use the drug warfarin as a model to demonstrate how pharmacogenetics when combined with fundamental principles of pharmacokinetic and pharmacodynamics can provide a powerful decision-support tool to optimize personalized therapeutics.