Expression of blood group‐related antigens in cholangiocarcinoma in relation to non‐neoplastic bile ducts
Expression of blood group‐related antigens in cholangiocarcinoma in relation to non‐neoplastic bile ducts
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胆管癌中血型相关抗原的表达与非肿瘤性胆管的关系
DOI：
10.1046/j.1365-2559.1996.343384.x
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发表时间：
1996
期刊：
影响因子：
6.4
通讯作者：
T. Terada
中科院分区：
文献类型：
--
作者：
H. Minato;Y. Nakanuma;T. Terada
血型相关抗原的异常表达已被报道在许多恶性肿瘤，然而，这种表达在胆管癌还没有被系统地检查。应用免疫组化方法检测了75例胆管癌（31例周围型，44例肝门型）血型相关抗原（A、B、H、Lewisa、LewisB、Lewisx、Lewisy、糖类抗原19 - 9和癌胚抗原）的表达。在非肿瘤性胆管中，A、B和H抗原在大胆管中表达，而Lewisa、B、y和碳水化合物抗原19 - 9在大胆管和小胆管中均表达。在非肿瘤性胆管中未发现Lewis和癌胚抗原。在胆管癌中，A、B和H抗原在肝门型中比在周围型中更常见，尽管差异不显著。血型相关抗原，特别是A、Lewisa、B、y、癌胚抗原和碳水化合物抗原19 - 9的表达在高分化腺癌的肿瘤细胞中很常见，而它们的免疫反应性在低分化腺癌中不太常见。这些抗原在高分化腺癌细胞中的超核和管腔表达频繁，而在低分化腺癌和腺鳞癌中，这些抗原的弥漫性、细胞膜和间质表达相对频繁。非肿瘤性胆管和胆管癌的A、B和H免疫反应性与宿主血型一致。这些结果表明，胆管癌中血型相关抗原的表达和细胞内分布与胆管癌的分化有关，可能与母体结构有关。
The abnormal expression of blood group related antigens has been reported in many malignant tumours; however, such expression in cholangiocarcinoma has not been examined systematically. The expression of blood group‐related antigens (A, B, H, Lewisa, Lewisb, Lewisx, Lewisy, carbohydrate antigen 19‐9 and carcinoembryonic antigen) was investigated immunohistochemically in 75 cases of cholangiocarcinoma (31 peripheral type and 44 hilar type). In non‐neoplastic bile ducts, A, B, and H antigens were expressed in large bile ducts, while Lewisa,b,y and carbohydrate antigen 19‐9 were variably expressed in both large and small bile ducts. Lewisx and carcinoembryonic antigen was not found in non‐neoplastic bile ducts. In cholangiocarcinomas, A, B, and H, antigens were more frequent in the hilar type than in the peripheral type, although the difference was not significant. The expression of the blood‐group related antigens, particularly A, Lewisa,b,y, carcinoembryonic antigen, and carbohydrate antigen 19‐9, was frequent in the tumour cells in well differentiated adenocarcinomas, while their immunoreactivity was less frequent in poorly differentiated adenocarcinomas. The superanuclear and luminal expression of these antigens in carcinoma cells was frequent in well differentiated adenocarcinomas, and the diffuse, cell membranous and stromal expression of these antigens was relatively frequent in poorly differentiated adenocarcinomas and adenosquamous carcinoma. The A, B, and H immunoreactivity of both non‐neoplastic bile ducts and cholangiocarcinomas was consistent with the host blood group type. These findings suggest that both the expression and intracellular distribution of blood group‐related antigens in cholangiocarcinoma are related to the differentiation of cholangiocarcinoma and, possibly, to the parent structure.
O 型血个体肿瘤中表达的不相容 A 抗原：免疫化学、免疫组织学和酶学表征。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Clausen,H;Hakomori,S;Graem,N;Dabelsteen,E
通讯作者：
Dabelsteen,E
实验性癌症研究中的人类单克隆抗体。
DOI：
--
发表时间：
1985
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Olsson,L
通讯作者：
Olsson,L
血型相关抗原作为人类癌症恶性潜能和异质性的标记。
影响因子：
3.3
作者：
Coon,JS;Weinstein,RS
通讯作者：
Weinstein,RS