Regulation of Chemokine Expression in the Tumor Microenvironment
Regulation of Chemokine Expression in the Tumor Microenvironment
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DOI：
10.1615/critrevimmunol.2014010062
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发表时间：
2014-01-01
影响因子：
1.3
通讯作者：
Fairchild, Robert L.
中科院分区：
文献类型：
--
作者：
Gorbachev, Anton V.;Fairchild, Robert L.
趋化因子是趋化性细胞因子，在免疫应答、造血、伤口愈合和肿瘤发生过程中对白细胞的稳态和炎症诱导的运输至关重要。尽管对趋化因子网络进行了三十年的深入研究，但在肿瘤生长过程中调节趋化因子表达的分子机制尚未得到很好的理解。在这篇综述中，我们集中在肿瘤生长和抗肿瘤免疫反应中的趋化因子的作用和肿瘤细胞调节趋化因子在肿瘤微环境中表达的分子机制。肿瘤用来调节趋化因子产生的多种机制，包括最近的研究（如DNA甲基化或趋化因子的翻译后亚硝基化）所揭示的机制。最后，我们讨论了如何理解这些调节机制可以用于癌症治疗，以抑制肿瘤生长和/或促进免疫介导的根除肿瘤。
Chemokines are chemotactic cytokines critical for homeostatic and inflammation-induced trafficking of leukocytes during immune responses, hematopoesis, wound healing, and tumorigenesis. Despite three decades of intensive study of the chemokine network, the molecular mechanisms regulating chemokine expression during tumor growth are not well understood. In this review, we focus on the role of chemokines in both tumor growth and antitumor immune responses and on molecular mechanisms employed by tumor cells to regulate chemokine expression in the tumor microenvironment. Multiple mechanisms used by tumors to regulate chemokine production, including those revealed by very recent studies (such as DNA methylation or post-translational nitrosylation of chemokines) are discussed. Concluding the review, we discuss how understanding of these regulatory mechanisms can be used in cancer therapy to suppress tumor growth and/or to promote immune-mediated eradication of tumors.