2-Acetaminopyridine:: A highly effective cocrystallizing agent
2-Acetaminopyridine:: A highly effective cocrystallizing agent
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DOI：
10.1021/cg050391z
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发表时间：
2006-02-01
影响因子：
3.8
通讯作者：
Desper, J
中科院分区：
文献类型：
--
作者：
Aakeröy, CB;Hussain, I;Desper, J
为了利用 2-氨基吡啶部分作为羧酸的结构和几何超分子补充，同时避免在非共价组装过程中将两个中性分子结构单元转化为离子对，2-乙酰氨基吡啶 (2-AApy) 已被探索作为一种潜在的共结晶剂。给出了八种共晶的晶体结构。每个都包含相同的预期氢键基序，并且没有从八种羧酸中的任何一个到吡啶部分的质子转移。这表明 2-AApy 非常有能力以可预测和合理的方式影响二元共晶的构建。
To take advantage of the 2-aminopyridine moiety as a structural and geometric supramolecular complement to carboxylic acids while avoiding transforming two neutral molecular building blocks into an ion-pair during noncovalent assembly, 2-acetaminopyridine (2-AApy) has been explored as a potential cocrystallizing agent. The crystal structures of eight cocrystals are presented. Each contain the same expected hydrogen-bonded motifs, and there has been no proton transfer from either of the eight carboxylic acids to the pyridine moiety. This demonstrates that 2-AApy is very capable of affecting the construction of binary cocrystals in a predictable and rationale manner.