Principles and results of high-intensity focused ultrasound for localized prostate cancer
Principles and results of high-intensity focused ultrasound for localized prostate cancer
复制标题
高强度聚焦超声治疗局限性前列腺癌的原理和结果
DOI：
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发表时间：
2004
影响因子：
4.8
通讯作者：
A. Gelet
中科院分区：
文献类型：
--
作者：
M. Colombel;A. Gelet
聚焦超声在大量的治疗应用中有希望。高强度聚焦超声（HIFU）可以通过凝固性坏死杀死组织，这一点早已为人们所知。然而，直到最近几年，随着高功率超声阵列和非侵入性监测方法的发展，实际的临床应用才成为可能。在过去的十年中，高强度聚焦超声已被改编并用于治疗局限性前列腺癌，目前已在欧洲上市。本文就前列腺高强度聚焦超声的临床前研究和临床进展以及本中心和国际研究的早期临床结果进行综述。早期结果表明，前列腺HIFU是有效的，以获得局部控制低，中风险局限性前列腺癌，但是，长期随访仍然需要估计的疗效，前列腺HIFU的具体癌症死亡率。这使得HIFU成为不适合根治性治疗的患者的可行替代方案。
Focused ultrasound holds promise in a large number of therapeutic applications. It has long been known that high-intensity focused ultrasound (HIFU) can kill tissue through coagulative necrosis. However, it is only in recent years that practical clinical applications are becoming possible, with the development of high-power ultrasound arrays and noninvasive monitoring methods. In the last decade, HIFU have been adapted and used to treat localized prostate cancer and it is now commercially available in Europe. In this article, preclinical studies and clinical development of prostate HIFU as well as early clinical results from our center and international studies are reviewed. Early results demonstrated that prostate HIFU is efficient to obtain local control for low- and intermediate-risk localized prostate cancer; however, long-term follow-up is still needed to estimate the efficacy of prostate HIFU in terms of specific cancer mortality. This makes HIFU a viable alternative in patients not candidate for radical therapy.
小型圆柱形超声波源，用于通过体腔或间质植入物诱导高温。
DOI：
10.3109/02656739309022539
发表时间：
1993
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Hynynen,K;Davis,KL
通讯作者：
Davis,KL