Solution, surface, and single molecule platforms for the study of DNA-mediated charge transport
Solution, surface, and single molecule platforms for the study of DNA-mediated charge transport
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DOI：
10.1039/c2cp41602f
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发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Barton, Jacqueline K.
中科院分区：
文献类型：
--
作者：
Muren, Natalie B.;Olmon, Eric D.;Barton, Jacqueline K.
DNA的结构核心，一堆连续的芳香杂环，碱基对，沿着螺旋轴向下延伸，产生了这个分子迷人的电子特性，这对生命至关重要。我们的实验室和其他实验室开发了多种实验平台来研究DNA传导电荷的能力，称为DNA介导的电荷传输（DNA CT）。在这里，我们提出了DNA CT实验在溶液，表面和单分子的概述，共同提供了广泛和一致的观点，这种化学的基本特征。DNA CT可以在长分子距离上进行，但对碱基对堆叠的扰动非常敏感。我们将讨论如何利用来自不同平台的数据建立这个基础，以告知DNA CT的机制描述，并激发其研究的下一个平台：生物体和分子电子学。
The structural core of DNA, a continuous stack of aromatic heterocycles, the base pairs, which extends down the helical axis, gives rise to the fascinating electronic properties of this molecule that is so critical for life. Our laboratory and others have developed diverse experimental platforms to investigate the capacity of DNA to conduct charge, termed DNA-mediated charge transport (DNA CT). Here, we present an overview of DNA CT experiments in solution, on surfaces, and with single molecules that collectively provide a broad and consistent perspective on the essential characteristics of this chemistry. DNA CT can proceed over long molecular distances but is remarkably sensitive to perturbations in base pair stacking. We discuss how this foundation, built with data from diverse platforms, can be used both to inform a mechanistic description of DNA CT and to inspire the next platforms for its study: living organisms and molecular electronics.