Interaction of desipramine with steroid hormones on experimental anxiety
Interaction of desipramine with steroid hormones on experimental anxiety
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DOI：
10.1016/s0306-4530(99)00042-6
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发表时间：
2000-02-01
影响因子：
3.7
通讯作者：
Fernández-Guasti, A
中科院分区：
文献类型：
--
作者：
Martínez-Mota, L;Estrada-Camarena, E;Fernández-Guasti, A
本研究分析了苯甲酸雌二醇和/或孕酮是否与去甲丙咪嗪（去甲丙咪嗪）相互作用以减少实验焦虑。所用的焦虑动物模型是条件性防御性埋藏试验。在切除卵巢的大鼠中绘制了雌二醇（0.625、1.25和2.5 mg/kg，每24 h，共21天）、苯甲酸雌二醇（0.5、1.0、2.0和4.0 μ g/大鼠，48 h）和孕酮（0.5、1.0和2.0 mg/大鼠，-4 h）的剂量反应曲线。剂量依赖性地降低了累积掩埋时间，认为这种作用类似于抗焦虑。孕激素在最高剂量下降低了埋藏，而苯甲酸雌二醇对防御性埋藏没有影响。两种：孕酮（0.5 mg/大鼠）和苯甲酸雌二醇（4.0 μ g/大鼠）在注射阈下剂量的孕酮（1.25 mg/kg）时能够降低累积掩埋行为。此外，连续给药（分别在试验前48 h和4 h）的雌二醇苯甲酸酯和孕酮的组合物（1.25 mg/kg）的效果也产生了协同降低掩埋行为。在一般情况下，治疗产生的埋葬行为潜伏期没有变化，无论是在自发性amphibia或伤害性感受。它的结论是，单用雌二醇或与孕酮联合使用时，Escherichia coli协同其抗焦虑作用。目前的数据提供了实验证据，表明激素和抗抑郁药之间的相互作用。结果进行了讨论的基础上，类固醇和β-氨基丁酸能受体或GABA能受体之间的相互作用。(C)2000爱思唯尔科技有限公司版权所有。
The present study analyzes if estradiol benzoate and/or progesterone interact with desmethylimipramine (DMI) to diminish experimental anxiety. The animal model of anxiety used was the conditioned defensive burying test. Dose response curves for DMI (0.625, 1.25 and 2.5 mg/kg, every 24 h, during 21 days), estradiol benzoate (0.5, 1.0, 2.0 and 4.0 mu g/rat, 48 h) and progesterone (0.5, 1.0 and 2.0 mg/rat, -4 h) were made in ovariectomized rats. DMI per se decreased dose dependently the cumulative burying time, an effect considered as anxiolytic-like. Progesterone produced a decrease in burying at the highest dose, while estradiol benzoate had no effect on defensive burying. Both: progesterone (0.5 mg/rat) and estradiol benzoate (4.0 mu g/rat) were able to decrease the cumulative burying behavior when injected with a subthreshold dose of DMI (1.25 mg/kg). In addition, the effect of DMI (1.25 mg/kg) plus the combination of estradiol benzoate and progesterone, sequentially administered (48 h and 4 h before the tests, respectively), also produced a synergistic decrease in burying behavior. In general, the treatments produced no changes in burying behavior latency, neither in spontaneous ambulation or in nociception. It is concluded that DMI synergizes its anxiolytic-like effect when administered with estradiol alone or in combination with progesterone. Present data provide experimental evidence suggesting an interaction between hormones and antidepressants. Results are discussed on the basis of the interaction between steroids and serotonegic or GABAergic receptors. (C) 2000 Elsevier Science Ltd. All rights reserved.