Clinical trials update from the European Society of Cardiology Heart Failure meeting: SHAPE, BRING-UP 2 VAS, COLA II, FOSIDIAL, BETACAR, CASINO and meta-analysis of cardiac resynchronisation therapy
Clinical trials update from the European Society of Cardiology Heart Failure meeting: SHAPE, BRING-UP 2 VAS, COLA II, FOSIDIAL, BETACAR, CASINO and meta-analysis of cardiac resynchronisation therapy
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DOI：
10.1016/j.ejheart.2004.07.007
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发表时间：
2004-08-01
影响因子：
18.2
通讯作者：
Clark, AL
中科院分区：
文献类型：
--
作者：
Coletta, AP;Cleland, JGF;Clark, AL
本文是关于心力衰竭领域最新研究进展的一系列报道。报告了2004年6月在波兰弗罗茨瓦夫举行的欧洲心脏病学会心力衰竭最新会议上的主要报告。SHAPE研究确定了教育全科医生(GP)的必要性，以便在初级保健中优化心力衰竭的治疗。BROUP-UP 2 VAS显示，认知障碍在老年心力衰竭患者中非常常见，这些患者需要专家护理。在观察性Cola II研究中，卡维地洛对老年心力衰竭患者显示出良好的耐受性和有效性。在FOSIDIAL对终末期肾病患者的研究中，福辛普利在降低这些高危患者的心血管事件发生率方面没有显示出比安慰剂有任何益处。BETACAR研究表明，卡维地洛和美托洛尔对左心室射血分数的影响相似(分别为+13.1%和+12.0%)。根据最近发表的伴随研究，报告了赌场研究的修订死亡率数据和心脏再同步治疗对死亡率影响的荟萃分析。(C)2004年欧洲心脏病学会。爱思唯尔出版，版权所有。
This article continues a series of reports on recent research developments in the field of heart failure. Key presentations made at the European Society of Cardiology Heart Failure Update meeting, held in Wroclaw, Poland, in June 2004 are reported. The SHAPE study identified a need to educate general practitioners (GPs) in order to optimise treatment of heart failure in primary care. BRING-UP 2 VAS showed that cognitive impairment is very common in elderly heart failure patients and that these patients require specialist care. Carvedilol was shown to be well tolerated and effective in elderly heart failure patients in the observational COLA II study. In the FOSIDIAL study of patients with end-stage renal disease, fosinopril showed no benefit over placebo in reducing the incidence of cardiovascular events in these high-risk patients. The BETACAR study showed that carvedilol and metoprolol produced a similar effect on left ventricular ejection fraction (+ 13.1% and + 12.0%, respectively). Revised mortality data for the CASINO study and a meta-analysis of the effects of cardiac resynchronisation therapy on mortality in the light of the recently published COMPANION study are reported. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.