Vagal regulation of gastric prostaglandin E2 release by central TRH in rats.
Vagal regulation of gastric prostaglandin E2 release by central TRH in rats.
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大鼠中枢TRH对胃前列腺素E2释放的迷走神经调节。
DOI：
10.1152/ajpgi.1993.264.2.g231
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Tache,Y
中科院分区：
文献类型：
--
作者：
Yoneda,M;Tache,Y
在尿烷麻醉大鼠中研究了稳定的促甲状腺激素释放激素（TRH）类似物RX 77368诱导胃前列腺素E2（PGE 2）迷走神经释放的中枢作用。脑池内RX 77368（1.5- 1，000 ng）以剂量依赖性方式增加植入粘膜下层体的透析纤维灌注液中3小时测量的胃PGE 2水平。静脉注射RX 77368（1，000 ng）无影响。RX 77368（1.5 ng）对胃PGE 2释放的刺激作用被吲哚美辛和双侧颈部迷走神经切断术阻断。奥美拉唑未改变PGE 2对3 ng RX 77368的反应，1，000 ng剂量诱导的PGE 2释放降低39%。RX 77368（1.5 ng）本身不影响酸分泌，但在吲哚美辛预处理大鼠中将酸分泌量增加至117 +/- 18 mumol/2 h。吲哚美辛也使3 ng剂量RX 77368的酸反应增加了97%，但RX 77368的最大有效剂量的作用未改变。这些结果表明，RX 77368在脑中诱导胃PGE 2分泌的迷走神经依赖性刺激，其具有生物活性，可降低对次最大剂量TRH类似物的酸反应。这些数据表明，延髓TRH在胃PGE 2释放的中枢迷走神经调节中可能发挥作用。
The central action of the stable thyrotropin-releasing hormone (TRH) analogue, RX 77368, to induce vagal release of gastric prostaglandin E2 (PGE2) was investigated in urethan-anesthetized rats. Intracisternal RX 77368 (1.5-1,000 ng) dose dependently increased gastric PGE2 levels measured for 3 h in the perfusate of dialysis fibers implanted into the corpus submucosa. RX 77368 injected intravenously (1,000 ng) had no effect. The stimulatory action of RX 77368 (1.5 ng) on gastric PGE2 release was blocked by indomethacin and bilateral cervical vagotomy. Omeprazole did not alter the PGE2 response to 3 ng of RX 77368 and reduced by 39% PGE2 release induced by the 1,000-ng dose. RX 77368 (1.5 ng) by itself did not influence acid secretion but increased acid output to 117 +/- 18 mumol/2 h in indomethacin-pretreated rats. Indomethacin also increased by 97% the acid response to the 3-ng dose of RX 77368, but the effect of a maximal effective dose of RX 77368 was not modified. These results indicate that RX 77368 acts in the brain to induce a vagal-dependent stimulation of gastric PGE2 secretion which is biologically active to reduce the acid response to submaximal doses of TRH analogue. These data suggest a possible role of medullary TRH in the central vagal regulation of gastric PGE2 release.