The olfactory receptor gene superfamily of the mouse
The olfactory receptor gene superfamily of the mouse
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DOI：
10.1038/nn800
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发表时间：
2002-02-01
影响因子：
25
通讯作者：
Firestein, S
中科院分区：
文献类型：
--
作者：
Zhang, XM;Firestein, S
嗅觉受体（OR）基因是脊椎动物中最大的基因超家族。我们通过全面的数据挖掘策略，从几乎完整的 Celera 小鼠基因组中鉴定出了小鼠 OR 基因。我们发现了1,296个小鼠OR基因（包括20%相似的假基因），可分为228个家族。 OR 基因分布在除 12 和 Y 之外的所有小鼠染色体上的 27 个簇中。一个 OR 基因簇与介导特定嗅觉丧失的已知基因座相匹配，表明嗅觉丧失可能直接归因于受体的丧失。小鼠基因组中大量表面功能“类似鱼”的 I 类 OR 基因可能在哺乳动物嗅觉中发挥重要作用。人类 OR 覆盖了与小鼠 OR 相似的“受体空间”，这表明人类嗅觉系统保留了识别广泛化学物质的能力，尽管与小鼠相比，人类丢失了近三分之二的 OR 基因。
Olfactory receptor (OR) genes are the largest gene superfamily in vertebrates. We have identified the mouse OR genes from the nearly complete Celera mouse genome by a comprehensive data mining strategy. We found 1,296 mouse OR genes (including similar to20% pseudogenes), which can be classified into 228 families. OR genes are distributed in 27 clusters on all mouse chromosomes except 12 and Y. One OR gene cluster matches a known locus mediating a specific anosmia, indicating the anosmia may be due directly to the loss of receptors. A large number of apparently functional 'fish-like' Class I OR genes in the mouse genome may have important roles in mammalian olfaction. Human ORs cover a similar 'receptor space' as the mouse ORs, suggesting that the human olfactory system has retained the ability to recognize a broad spectrum of chemicals even though humans have lost nearly two-thirds of the OR genes as compared to mice.