Mucin core protein expression in serrated polyps of the large intestine
Mucin core protein expression in serrated polyps of the large intestine
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DOI：
10.1007/s00428-010-0959-8
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发表时间：
2010-10-01
期刊：
影响因子：
3.5
通讯作者：
Tsuneyoshi, Masazumi
中科院分区：
文献类型：
--
作者：
Fujita, Kohei;Hirahashi, Minako;Tsuneyoshi, Masazumi
无柄锯齿状腺瘤(SSA)被认为是微卫星不稳定的结直肠癌的先兆。然而，如何区分锯齿状病变的组织学标准尚未完全确立，SSA和增生性息肉(HPS)之间存在组织学上的重叠，尤其是微泡型。在这项研究中，我们在对组织学进行回顾的基础上，旨在阐明粘蛋白表型在鉴别SSA中的潜在作用。应用免疫组织化学方法检测65例微泡型HPS、51例SSA和72例传统锯齿状腺瘤中粘蛋白核心蛋白(MUC2、MUC5AC和MUC6)的表达。SSAS具有不同于HPS和TSA的临床病理和形态特征。SSA中MUC6阳性率(39%)明显高于TSA(4%)和HPS(19%)(P<；0.001和P=0.0107)。右侧HPS比左侧HPS表达MUC6的频率更高(分别为60%和4%；P<；0.0001)，但SSA和TSA没有地区差异。这些发现提示，粘蛋白核心蛋白表达的测定不足以区分SSA和其他类型的锯齿状息肉，而右半结肠和SSA的微泡型HPS可能属于同一粘蛋白谱。
Sessile serrated adenoma (SSA) has been proposed as a precursor to microsatellite-unstable colorectal carcinoma. However, histological criteria dictating how to differentiate serrated lesions have not been completely established, and a histological overlap exists between SSA and hyperplastic polyps (HPs), particularly the microvesicular type. In this study, based on a critical review of histology, we aimed to elucidate the potential utility of the mucin phenotype in the identification of SSA. We evaluated mucin core protein expression (MUC2, MUC5AC, and MUC6) by immunohistochemical stain in 65 cases of microvesicular-type HPs, 51 SSAs, and 72 traditional serrated adenomas (TSAs). SSAs had clinicopathological and morphological features distinct from those of HPs and TSAs. MUC6 was more frequently positive in SSAs (39%) than in TSAs (4%) and HPs (19%) (P < 0.001 and P = 0.0107, respectively). Right-sided HPs more frequently expressed MUC6 than did left-sided HPs (60% vs. 4%, respectively; P < 0.0001), but SSAs and TSAs showed no regional differences. These findings suggest that determination of mucin core protein expression is insufficient for differentiating SSAs from other types of serrated polyps, and that microvesicular-type HPs of the right colon and SSAs may belong to the same mucin spectrum.