Minireview: Long noncoding RNAs: new "links" between gene expression and cellular outcomes in endocrinology.
Minireview: Long noncoding RNAs: new "links" between gene expression and cellular outcomes in endocrinology.
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DOI：
10.1210/me.2013-1113
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发表时间：
2013-07
影响因子：
--
通讯作者：
Miao Sun;Miao Sun;W. Kraus
中科院分区：
文献类型：
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作者：
Miao Sun;Miao Sun;W. Kraus
测序技术的最新进展表明，基因组被广泛转录，产生了大量的非编码RNA。这些包括长链非编码RNA（lncRNA），不编码蛋白质的mRNA样分子，它们作为一类新的RNA出现，在各种细胞过程中发挥重要作用。正在进行的研究揭示了关于lncRNA的新见解，包括其生理功能，疾病关系和分子作用机制。已显示表征的lncRNA与其他RNA和蛋白质伴侣相互作用并调节其活性，导致转录和转录后调控过程的改变。在这篇综述中，我们总结了lncRNA的主要特征，其分子作用机制，生物学功能和治疗意义，特别是当它们应用于分子内分泌学领域时。此外，我们还简要介绍了分子生物学家如何开始探索这类新兴RNA分子的身份、机制和功能。
Recent advances in sequencing technologies have revealed that the genome is extensively transcribed, yielding a large repertoire of noncoding RNAs. These include long noncoding RNAs (lncRNAs), mRNA-like molecules that do not code for proteins, which are emerging as a new class of RNAs that play important roles in a variety of cellular processes. Ongoing studies are revealing new insights about lncRNAs, including their physiological functions, disease relationships, and molecular mechanisms of action. Characterized lncRNAs have been shown to interact with and modulate the activity of other RNAs and protein partners, leading to alterations in transcriptional and posttranscriptional regulatory processes. In this review, we summarize the key features of lncRNAs, their molecular mechanisms of action, biological functions, and therapeutic implications, particularly as they apply to the field of molecular endocrinology. In addition, we provide a brief overview of how molecular biologists are beginning to probe the identity, mechanisms, and functions of this emerging class of RNA molecules.