MEIOTIC DRIVE IN FEMALE MICE HETEROZYGOUS FOR THE HSR INSERTS ON CHROMOSOME-1
MEIOTIC DRIVE IN FEMALE MICE HETEROZYGOUS FOR THE HSR INSERTS ON CHROMOSOME-1
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DOI：
10.1017/s0016672300025325
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发表时间：
1990-04-01
影响因子：
1.5
通讯作者：
RUVINSKY, AO
中科院分区：
文献类型：
--
作者：
AGULNIK, SI;AGULNIK, AI;RUVINSKY, AO
1号染色体有一个或两个长的插入，以前在自然老鼠群体中发现过。本文分析了雅库茨克人1号染色体的两个插入片段的遗传。研究表明，杂合子雌性会将这种染色体传递给80%-85%的后代。在MⅡ进行的观察，结合重组数据，使我们得出结论，1号染色体优先通过插入到卵母细胞和卵子，而不是减数分裂的第一和第二极体，是造成扭曲分离的原因。此前还没有关于雌性哺乳动物减数分裂驱动这种效力的报道。讨论了驱动的可能机理。
Chromosome 1 with one or two long insertions have been previously found in natural mouse populations. The inheritance of chromosome 1 with two insertions from the Yakutsk population is analysed in this paper. It was demonstrated that heterozygous females transmit this chromosome to 80-85% of offspring. The observations made at M II, in conjunction with the recombination data, allowed us to conclude that preferential passage of the chromosome 1 with insertions to the oocyte and egg, rather than to the first and second polar bodies at meiosis, is the causative factor of the distorted segregation. A meiotic drive of such potency has not been previously reported for female mammals. The possible mechanism of the drive is discussed.