Using Dali for structural comparison of proteins.
Using Dali for structural comparison of proteins.
复制标题
DOI：
10.1002/0471250953.bi0505s14
复制
发表时间：
2006-07-01
影响因子：
--
通讯作者：
Plewczynski, Dariusz
中科院分区：
文献类型：
--
作者：
Holm, Liisa;Kaariainen, Sakari;Plewczynski, Dariusz
Dali程序被广泛用于对通过X射线晶体学或NMR确定的蛋白质结构进行自动比较。最熟悉的版本是Dali服务器，它执行数据库搜索，将用户提供的查询结构与已知结构数据库（PDB）进行比较，并通过电子邮件返回结构邻居列表。最近推出的DaliLite服务器将两个结构相互比较，并以交互方式可视化结果。Dali数据库是基于PDB内预先计算的所有对所有结构相似性的结构分类。由此产生的层次分类可以在Web上浏览，并链接到蛋白质序列分类资源。所有Dali资源使用相同的算法进行结构比较。用户可以使用Web运行Dali，也可以下载该程序在Linux计算机上本地运行。
The Dali program is widely used for carrying out automatic comparisons of protein structures determined by X-ray crystallography or NMR. The most familiar version is the Dali server, which performs a database search comparing a query structure supplied by the user against the database of known structures (PDB) and returns the list of structural neighbors by e-mail. The more recently introduced DaliLite server compares two structures against each other and visualizes the result interactively. The Dali database is a structural classification based on precomputed all-against-all structural similarities within the PDB. The resulting hierarchical classification can be browsed on the Web and is linked to protein sequence classification resources. All Dali resources use an identical algorithm for structure comparison. Users may run Dali using the Web, or the program may be downloaded to be run locally on Linux computers.