The molecular basis of lung cancer: molecular abnormalities and therapeutic implications.
The molecular basis of lung cancer: molecular abnormalities and therapeutic implications.
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DOI：
10.1186/1465-9921-4-12
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发表时间：
2003
影响因子：
5.8
通讯作者：
Carbone DP
中科院分区：
文献类型：
--
作者：
Massion PP;Carbone DP
在西方世界，肺癌是癌症相关死亡的头号原因。其发病率与吸烟高度相关，约10%的长期吸烟者最终将被诊断为肺癌，这突显了加强反烟草政策的必要性。在10%的无吸烟史的肺癌患者中，肺癌的环境或遗传原因通常不清楚。即使在高危人群中，也没有经过验证的肺癌筛查方法，而且在过去20年中，总体五年生存率没有明显变化。然而，在对这种疾病的理解方面已经取得了重大进展，我们开始看到这种知识转化为临床。在这篇综述中，我们将总结与肺癌发展相关的一系列事件的当前知识状况。从亚临床DNA损伤到显性侵袭性疾病，导致临床和分子异质性肿瘤的机制正在被揭开。这些损伤使细胞逃脱了细胞分裂、凋亡和侵袭的正常调控。虽然历史上所有亚型的非小细胞肺癌都得到了相同的治疗，但随着阶段的推移，最近的技术进步使人们更好地了解了疾病的分子分类，并为分子早期发现和有针对性的治疗策略提供了假设。
Lung cancer is the number one cause of cancer-related death in the western world. Its incidence is highly correlated with cigarette smoking, and about 10% of long-term smokers will eventually be diagnosed with lung cancer, underscoring the need for strengthened anti-tobacco policies. Among the 10% of patients who develop lung cancer without a smoking history, the environmental or inherited causes of lung cancer are usually unclear. There is no validated screening method for lung cancer even in high-risk populations and the overall five-year survival has not changed significantly in the last 20 years. However, major progress has been made in the understanding of the disease and we are beginning to see this knowledge translated into the clinic. In this review, we will summarize the current state of knowledge regarding the cascade of events associated with lung cancer development. From subclinical DNA damage to overt invasive disease, the mechanisms leading to clinically and molecularly heterogeneous tumors are being unraveled. These lesions allow cells to escape the normal regulation of cell division, apoptosis and invasion. While all subtypes of non-small cell lung cancer have historically been treated the same, stage-for-stage, recent technological advances have allowed a better understanding of the molecular classification of the disease and provide hypotheses for molecular early detection and targeted therapeutic strategies.
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DOI：
10.1073/pnas.95.20.11891
发表时间：
1998-09-29
影响因子：
11.1
作者：
Belinsky, SA;Nikula, KJ;Herman, JG
通讯作者：
Herman, JG
影响因子：
82.9
作者：
Beer, DG;Kardia, SLR;Hanash, S
通讯作者：
Hanash, S
DOI：
10.1073/pnas.93.9.4045
发表时间：
1996-04-30
影响因子：
11.1
作者：
Belinsky, SA;Nikula, KJ;Issa, JPJ
通讯作者：
Issa, JPJ
影响因子：
10.3
作者：
Burbee, DG;Forgacs, E;Minna, JD
通讯作者：
Minna, JD
影响因子：
9.6
作者：
CARBONE, DP;MITSUDOMI, T;MINNA, J
通讯作者：
MINNA, J