Factors associated with interest in initiating treatment for hepatitis C virus (HCV) infection among young HCV-infected injection drug users
Factors associated with interest in initiating treatment for hepatitis C virus (HCV) infection among young HCV-infected injection drug users
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DOI：
10.1086/427445
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发表时间：
2005-04-15
影响因子：
11.8
通讯作者：
Hagan, H
中科院分区：
文献类型：
--
作者：
Strathdee, SA;Latka, M;Hagan, H
目标。我们试图找出与美国3个城市感染丙型肝炎病毒的注射吸毒者(IDU)中接受丙型肝炎病毒(HCV)感染治疗兴趣的相关因素。对18~35岁丙型肝炎病毒感染者和人类免疫缺陷病毒血清阴性的注射吸毒者进行了行为、经历、对丙型肝炎病毒感染治疗的兴趣和戒毒意愿的调查。在未接受治疗的注射吸毒者(n=216)中，81.5%的人对丙型肝炎病毒感染的治疗感兴趣，但只有27.3%的人在被诊断为丙型肝炎病毒感染后去看过卫生保健提供者。在那些认为进行性肝病威胁很高的注射吸毒者、那些有正常护理来源的人、那些没有酒精依赖证据的人，以及那些戒毒准备分数较高的人中，对治疗丙型肝炎病毒感染的兴趣更大。在被卫生保健提供者告知有患肝硬变或肝癌风险的注射吸毒者中，对治疗丙型肝炎病毒感染的兴趣增加了7倍。改善提供者与患者之间的沟通，将药物滥用和丙型肝炎病毒的治疗结合起来，可能会增加开始治疗丙型肝炎病毒感染的注射吸毒者的比例。
Objective. We sought to identify factors associated with interest in receiving therapy for hepatitis C virus (HCV) infection among HCV-infected injection drug users (IDUs) in 3 United States cities.Methods. IDUs aged 18 - 35 years who were HCV-infected and seronegative for human immunodeficiency virus underwent surveys on behaviors, experience, and interest in treatment for HCV infection and readiness to quit drug use.Results. Among treatment-naive IDUs (n = 216), 81.5% were interested in treatment for HCV infection, but only 27.3% had seen a health-care provider since receiving a diagnosis of HCV infection. Interest in treatment for HCV infection was greater among IDUs with a high perceived threat of progressive liver disease, those with a usual source of care, those without evidence of alcohol dependence, and those with higher readiness scores for quitting drug use. Interest in treatment for HCV infection was 7-fold higher among IDUs who were told by their health-care provider that they were at risk for cirrhosis or liver cancer.Conclusions. Improving provider-patient communication and integrating treatments for substance abuse and HCV may increase the proportion of IDUs who initiate treatment for HCV infection.