Does low bone mineral density start in post-teenage years in women with type 1 diabetes?
Does low bone mineral density start in post-teenage years in women with type 1 diabetes?
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DOI：
10.2337/diacare.26.8.2365
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发表时间：
2003-08-01
期刊：
影响因子：
16.2
通讯作者：
Quattrin, T
中科院分区：
文献类型：
--
作者：
Liu, EY;Wactawski-Wende, J;Quattrin, T
目的-I型糖尿病与骨密度降低有关.然而，I型糖尿病骨质疏松症的自然史和发病机制尚不清楚。本研究的目的是评估与非糖尿病对照受试者相比，年轻女性I型糖尿病患者队列的BMD，并评估BMD与糖尿病病程、HbA（1c）、研究设计和方法-通过双能X射线骨密度测量扫描测量39名青少年的BMD，（年龄13 - 19岁）和33名患有I型糖尿病的青春期后女性（年龄20 - 37岁）和91名女性年龄匹配的对照受试者。血清骨钙素，胰岛素样生长因子-I，胰岛素样生长因子结合蛋白-3（IGFBP-3），糖化血红蛋白（1c），和尿N-端肽测定结果-调整年龄和体重指数后，骨密度值显着降低，在股骨颈和侧脊柱的妇女与年龄大于20岁的对照组相比，但不低于20岁的情况下，也不是在前后脊柱，手腕或整个身体。未发现BMD与糖尿病病程或血糖控制之间存在相关性。IGF-I，IGFBP-3，骨钙素和N-端肽在糖尿病受试者和对照subjects.CONCLUSIONS相似-这项研究表明，妇女与I型糖尿病表现出BMD的差异在生命早期的显着差异已经存在于后十几岁。这些年轻女性髋部骨密度较低可能部分解释了绝经后I型糖尿病女性髋部骨折发生率较高的原因。
OBJECTIVE - Type I diabetes has been associated with decreased bone mineral density (BMD). However, the natural history and etiopathogenesis of osteoporosis in type I diabetes are not clear. The aims of this study were to assess BMD in a cohort of young women with type I diabetes compared with nondiabetic control subjects and to evaluate the possible association of BMD with diabetes duration, HbA(1c), and biomarkers of bone metabolism.RESEARCH DESIGN AND METHODS - BMD was measured by dual-energy X-ray absortiometry scan in 39 teenage (age 13-19 years) and 33 post-teenage females (age 20-37 years) with type I diabetes and 91 female age-matched control subjects. Serum osteocalcin, IGF-I, IGF binding protein-3 (IGFBP-3), HbA(1c), and urine N-telopeptides were measured.RESULTS - After adjustment for age and BMI, BMD values were significantly lower at the femoral neck and lateral spine in women with type I diabetes older than age 20 years compared with control subjects but not in the case subjects younger than age 20 years, nor at the anterioposterior spine, wrist, or whole body. No association was found between BMD and diabetes duration or glycemic control. IGF-I, IGFBP-3, osteocalcin, and N-telopeptides were similar in diabetic subjects and control subjects.CONCLUSIONS - This study indicates that women With type I diabetes exhibit BMD differences early in life with significant differences already present in the post-teenage years. Lower hip BMD in these young women may explain, in part, the higher incidence of hip fracture experienced in postmenopausal women with type I diabetes.