lissoclin Disulfoxide, A Novel Dimeric Alkaloid from the Ascidian lissoclinum Sp.: Inhibitor of Interleukin-8 Receptors
lissoclin Disulfoxide, A Novel Dimeric Alkaloid from the Ascidian lissoclinum Sp.: Inhibitor of Interleukin-8 Receptors
复制标题
lissoclin 二亚砜，一种来自 Ascidian lissoclinum Sp. 的新型二聚生物碱：白细胞介素 8 受体抑制剂
DOI：
10.1080/10575639708041199
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Randall K. Johnson
中科院分区：
文献类型：
--
作者：
A. D. Patil;A. Freyer;L. Killmer;G. Zuber;B. Carté;A. Jurewicz;Randall K. Johnson
对南非海鞘Lissoclinum sp.的MeOH提取物进行生物测定导向分离，得到三种已知化合物和一种新的生物碱lissoclinin二亚砜(1)，其结构通过光谱数据的解释来确定。生物碱1对il - 8r α和il - 8r β受体的抑制作用IC50值分别为0.6和0.82 μM。
Abstract Bioassay-guided fractionation of the MeOH extract of the South African ascidian Lissoclinum sp. yielded three known compounds plus a novel alkaloid, lissoclin disulfoxide (1), whose structure was determined by interpretation of spectral data. Alkaloid 1 had IC50 values of 0.6 and 0.82 μM against the inhibition of IL-8 Rα and IL-8 Rβ receptors, respectively.