NEUROPATHOLOGIC CONSEQUENCES OF INTERNAL CAROTID-ARTERY OCCLUSION AND HEMORRHAGIC HYPOTENSION IN BABOONS
NEUROPATHOLOGIC CONSEQUENCES OF INTERNAL CAROTID-ARTERY OCCLUSION AND HEMORRHAGIC HYPOTENSION IN BABOONS
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DOI：
10.1161/01.str.21.3.428
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发表时间：
1990-03-01
期刊：
影响因子：
8.3
通讯作者：
FITCH, W
中科院分区：
文献类型：
--
作者：
GRAHAM, DI;MENDELOW, AD;FITCH, W
我们研究了8只麻醉和生理监测的成年狒狒（蓝头狒狒）; 4只单独进行出血性低血压，4只进行出血性低血压加单侧颈动脉闭塞。用氙-133测定脑血流量，用银-氯化银硬膜外电极记录脑电图，灌注固定后进行组织学检查。在仅经受低血压（平均动脉血压为28 mm Hg）的狒狒中，脑血流量为28.5 ± 0.5。5.0 ml/100 g/min，而在经受低血压加单侧颈动脉闭塞的狒狒中，其为21.8 ± 0.05。1.8 ml/100 g/min，平均动脉血压为27 mm Hg。在前一组中没有缺血性损伤，但在后一组中，有三只狒狒的动脉边界区和一只狒狒的大脑中动脉分布区出现坏死。我们的结论是，当结合低血压，单侧颈动脉闭塞可能会导致血流动力学缺血加重的动脉边界区的同侧大脑半球。
We studied eight anesthetized and physiologically monitored adult baboons (Papio cyanocephalus); four were subjected to hemorrhagic hypotension alone and four to hemorrhagic hypotension plus unilateral carotid artery occlusion. Cerebral blood flow was measured using xenon-133, the electroencephalogram was recorded using silver-silver chloride epidural electrodes, and histologic examination was carried out after perfusion-fixation. In the baboons subjected to hypotension alone (mean arterial blood pressure of 28 mm Hg) cerebral blood flow was 28.5 .+-. 5.0 ml/100 g/min, whereas in the baboons subjected to hypotension plus unilateral carotid artery occlusion it was 21.8 .+-. 1.8 ml/100 g/min at a mean arterial blood pressure of 27 mm Hg. There was no ischemic damage in the former group, but in the latter group there was necrosis in the arterial boundary zones of three baboons and in the distribution of the middle cerebral artery in one. We conclude that, when combined with hypotension, unilateral carotid artery occlusion may lead to hemodynamic ischemia accentuated in the arterial boundary zones of the ipsilateral cerebral hemisphere.