Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension
Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension
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DOI：
10.1016/j.biortech.2009.07.068
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发表时间：
2010-01-01
影响因子：
11.4
通讯作者：
Shetty, Kalidas
中科院分区：
文献类型：
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作者：
Cheplick, Susan;Kwon, Young-In;Shetty, Kalidas
不同草莓品种的果实提取物被评估其对与2型糖尿病和相关高血压相关的高血糖症的饮食管理的潜力。使用水果提取物评估了对α-淀粉酶、α-葡萄糖苷酶和血管紧张素-1转换酶（ACE）活性的体外抑制作用，并将其与酚类含量和抗氧化活性相关。品种间酚类抗氧化活性和对目标病害相关酶的抑制活性存在显著差异。Honeoye，Idea和宝石品种表现出中度α-淀粉酶抑制。草莓品种，在一般情况下，表现出均匀的α-葡萄糖苷酶抑制与Ovation具有最高的抑制活性。宝石和Ovation品种的水提取物有中度ACE抑制相比，在其他品种中观察到的低抑制。具有α-葡萄糖苷酶和ACE联合抑制潜力以及具有中度或低度α-淀粉酶抑制潜力的草莓品种可能成为高血糖相关2型糖尿病和高血压相关并发症的潜在管理目标。(C)2009爱思唯尔有限公司保留所有权利。
Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension. In vitro inhibition of alpha-amylase, alpha-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitory activity for the targeted disease relevant enzymes. Honeoye, Idea, and jewel cultivars exhibited moderate alpha-amylase inhibition. Strawberry cultivars, in general, exhibited uniform alpha-glucosidase inhibition with Ovation having the highest inhibitory activity. Water extracts of Jewel and Ovation cultivars had moderate ACE inhibition compared to low inhibition observed in other cultivars. Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension. (C) 2009 Elsevier Ltd. All rights reserved.