Self-Propelled Janus Mesoporous Silica Nanomotors with Sub-100 nm Diameters for Drug Encapsulation and Delivery
Self-Propelled Janus Mesoporous Silica Nanomotors with Sub-100 nm Diameters for Drug Encapsulation and Delivery
复制标题
用于药物封装和输送的直径低于 100 nm 的自驱动 Janus 介孔二氧化硅纳米电机
DOI：
10.1002/cphc.201402111
复制
发表时间：
2014-08-04
期刊：
影响因子：
2.9
通讯作者：
He, Qiang
中科院分区：
文献类型：
--
作者：
Xuan, Mingjun;Shao, Jingxin;He, Qiang
本文描述了一种新型的直径约为75纳米、可作为药物载体的自推进Janus纳米马达的合成。Janus纳米马达基于介孔二氧化硅纳米颗粒（MSNs），带有铬/铂金属帽，通过分解过氧化氢产生氧气作为驱动力，速度可达20.2 μ ms(-1)（约每秒267个身长）。通过跟踪自组装荧光显微镜记录的单个粒子的运动，计算了不同H2O2浓度下纳米马达的扩散系数D，该系数明显大于自由布朗运动。单个Janus MSN纳米马达的牵引力估计约为13.47 X 10(-15) n。最后，细胞内定位和体外药物释放实验表明，在相同培养时间和颗粒浓度下，Janus MSN纳米马达进入细胞的数量多于MSNs，同时，载于Janus MSN纳米马达的抗癌药物盐酸多柔比星可以通过细胞内脂质双分子层的生物降解缓慢释放。
The synthesis of an innovative self-propelled Janus nanomotor with a diameter of about 75 nm that can be used as a drug carrier is described. The Janus nanomotor is based on mesoporous silica nanoparticles (MSNs) with chromium/platinum metallic caps and propelled by decomposing hydrogen peroxide to generate oxygen as a driving force with speeds up to 20.2 mu ms(-1) (about 267 body lengths per second). The diffusion coefficient (D) of nanomotors with different H2O2 concentrations is calculated by tracking the movement of individual particles recorded by means of a self-assembled fluorescence microscope and is significantly larger than free Brownian motion. The traction of a single Janus MSN nanomotor is estimated to be about 13.47 X 10(-15) N. Finally, intracellular localization and drug release in vitro shows that the amount of Janus MSN nanomotors entering the cells is more than MSNs with same culture time and particle concentrations, meanwhile anticancer drug doxorubicin hydrochloride loaded in Janus MSNs can be slowly released by biodegradation of lipid bilayers in cells.