Lymphocyte subpopulations in bronchoalveolar lavage fluid in asbestos workers.
Lymphocyte subpopulations in bronchoalveolar lavage fluid in asbestos workers.
复制标题
石棉工人支气管肺泡灌洗液中的淋巴细胞亚群。
DOI：
--
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
R. Rudd
中科院分区：
文献类型：
--
作者：
A. Gellert;M. Macey;S. Uthayakumar;A. Newland;R. Rudd
我们检测了29名石棉工人的外周血和支气管肺泡灌洗液（BAL）淋巴细胞亚群，其中10名有石棉肺的临床或放射学证据，19名无石棉肺。13名对照者的外周血淋巴细胞亚群也进行了测定。29名石棉工人的BAL液中OKT 4：OKT 8（T辅助细胞/诱导细胞：T抑制细胞/细胞毒性淋巴细胞）的平均比值为0.96（范围，未检测到3.33），显著低于外周血中的1.76（1.33 ~ 2.67）（p <0.001）。10例石棉肺患者、19例无石棉肺石棉工人和13例正常对照者外周血OKT_4：OKT_8比值无显著性差异;石棉肺患者和无石棉肺石棉工人BAL液OKT_4：OKT_8比值无显著性差异。在整个组中，暴露于石棉超过5年的人中有83%显示OKT 4：OKT 8比值小于1.2，而暴露于石棉少于5年的人中，80%显示比值大于1.2（p小于0.02）。OKT 4：OKT 8比值与临床、影像学或生理学变量之间没有其他关系。
We examined peripheral blood and bronchoalveolar lavage (BAL) fluid lymphocyte subpopulations in 29 asbestos workers, 10 with and 19 without clinical or radiologic evidence of asbestosis. Peripheral blood lymphocyte subpopulations were also measured in 13 control subjects. The mean OKT4:OKT8 (T-helper/inducer:T-suppressor/cytotoxic lymphocyte) ratio in BAL fluid in the 29 asbestos workers was 0.96 (range, not detected to 3.33), significantly less than 1.76 (1.33 to 2.67) in peripheral blood (p less than 0.001). There were no significant differences in OKT4:OKT8 ratios in peripheral blood between the 10 patients with asbestosis, the 19 asbestos workers without asbestosis, and the 13 normal control subjects or in the OKT4:OKT8 ratios in BAL fluid between patients with asbestosis and asbestos workers without asbestosis. In the group as a whole, 83% of those who had suffered more than 5 yr of exposure to asbestos showed OKT4:OKT8 ratios less than 1.2, whereas in those who had suffered fewer than 5 yr of exposure, 80% showed ratios greater than 1.2 (p less than 0.02). No other relationships between OKT4:OKT8 ratios and clinical, radiographic, or physiologic variables were observed.