Skeletal muscle metabolism in heart failure: a 31P nuclear magnetic resonance spectroscopy study of leg muscle.
Skeletal muscle metabolism in heart failure: a 31P nuclear magnetic resonance spectroscopy study of leg muscle.
复制标题
心力衰竭中的骨骼肌代谢：腿部肌肉的 31P 核磁共振波谱研究。
DOI：
10.1042/cs0790583
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发表时间：
1990
期刊：
影响因子：
6
通讯作者：
G. Radda
中科院分区：
文献类型：
--
作者：
L. Arnolda;M. Conway;M. Dolecki;H. Sharif;B. Rajagopalan;J. Ledingham;P. Sleight;G. Radda
1.采用31 P核磁共振波谱法研究了7例轻度至中度慢性心力衰竭患者和5例健康对照者的腓肠肌。光谱收集在休息和增量，间歇性，运动方案。在同一项研究中，在短暂中断运动期间测量了血流量。2.磷酸肌酸/（磷酸肌酸加无机磷酸盐）的比率低于心力衰竭患者在1.5 W的运动率比对照组，虽然细胞内pH值和血流量相似。3.心力衰竭患者在1.5 W运动时，胞浆游离腺苷5 '-二磷酸浓度显著高于对照组。4.虽然心力衰竭患者达到的最大负荷量不到对照组的一半，但心力衰竭患者在最大负荷时的pH值和磷酸肌酸/（磷酸肌酸加无机磷酸盐）比值较低。心力衰竭患者在最大运动量时的血流量低于对照组，这与减少的工作负荷一致。5.运动引起的腓肠肌磷酸肌酸消耗比先前描述的心力衰竭患者前臂的磷酸肌酸消耗更严重。6.骨骼肌代谢异常可能导致心力衰竭运动不耐受，特别是在次极量运动期间。
1. The gastrocnemius muscle of seven patients with mild to moderate chronic heart failure and of five healthy control subjects was studied using 31P nuclear magnetic resonance spectroscopy. Spectra were collected at rest and during an incremental, symptom-limited, exercise protocol. Blood flow was measured in the same study during brief interruptions to exercise. 2. The phosphocreatine/(phosphocreatine plus inorganic phosphate) ratio was lower in patients with heart failure than in control subjects at an exercise rate of 1.5 W, although intracellular pH and blood flow were similar. 3. The cytosolic free adenosine 5'-diphosphate concentration was markedly increased in patients with heart failure exercising at 1.5 W compared with control subjects exercising at the same workload. 4. Although the maximum workload achieved by patients with heart failure was less than half of that reached by control subjects, the pH and the phosphocreatine/(phosphocreatine plus inorganic phosphate) ratio were lower in patients with heart failure at maximal load. Blood flow was less at maximal exercise in patients with heart failure than in control subjects in keeping with the reduced work load. 5. The phosphocreatine depletion induced in the gastrocnemius muscle by exercise was more severe than previously described in the forearm of patients with heart failure. 6. Metabolic abnormalities in skeletal muscle may contribute to exercise intolerance in heart failure, particularly during submaximal exercise.