MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects
MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects
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DOI：
10.1016/s0730-725x(98)00155-6
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发表时间：
1999-02-01
影响因子：
2.5
通讯作者：
Mintz, J
中科院分区：
文献类型：
--
作者：
Bartzokis, G;Cummings, JL;Mintz, J
使用磁共振成像（MRI）方法在体内评估早发和晚发帕金森病（PD）受试者锥体外系系统中的组织铁水平。该方法包括在高场和低场MRI仪器中扫描受试者，测量组织松弛率（R-2），并计算场相关R-2增加（FDRI），即两种MRI仪器测量的R-2之间的差异。在组织中，已知只有铁蛋白铁以场依赖的方式增加R-2， FDRI测量是该组织铁池的特定测量。研究对象为两组男性PD患者和两组年龄匹配的正常对照男性。两组6名PD患者由早发或晚发（60岁之前或之后）PD患者组成，FDRI在5个皮质下结构：黑质网状（SNR）、黑质致密（SNC）、苍白球、壳核和尾状核以及一个比较区域进行测量；额叶白质。早发PD受试者在信噪比、SNC、壳核和苍白球的FDRI显著（p < 0.05）增加，而晚发PD受试者在信噪比中的FDRI显著降低。控制疾病持续时间或结构大小并没有显著改变结果。已发表的死后研究表明，老年PD患者SN中铁蛋白水平下降，游离铁水平升高，这与我们在晚发PD样本中观察到的FDRI下降一致，这与死后PD样本的年龄密切匹配。FDRI的研究结果表明PD中存在铁代谢失调，并且这种失调在早发和晚发PD中可能有所不同，(C) 1999 Elsevier Science Inc。
Tissue iron levels in the extrapyramidal system of earlier- and later-onset Parkinson's disease (PD) subjects were evaluated in vivo using a magnetic resonance imaging (MRI) method. The method involves scanning subjects in both high- and low-field MRI instruments, measuring tissue relaxation rate (R-2), and calculating the field-dependent R-2 increase (FDRI) which is the difference between the R-2 measured with the two MRI instruments. In tissue, only ferritin iron is known to increase R-2 in a field-dependent manner and the FDRI measure is a specific measure of this tissue iron pool. Two groups of male subjects with PD and two age-matched groups of normal control males were studied. The two groups of six subjects with PD consisted of subjects with earlier- or later-onset (before or after age 60) PD, FDRI was measured in five subcortical structures: the substantia nigra reticulata (SNR), substantia nigra compacta (SNC), globus pallidus, putamen, and caudate nucleus, and in one comparison region; the frontal white matter. Earlier-onset PD subjects had significant (p < 0.05) increases in FDRI in the SNR, SNC, putamen, and globus pallidus, while later-onset PD subjects had significantly decreased FDRI in the SNR when compared to their respective age-matched controls. Controlling for illness duration or structure size did not meaningfully alter the results. Published post-mortem studies on SN iron levels indicate decreased ferritin levels and increased free iron levels in the SN of older PD subjects, consistent with the decreased FDRI observed in our later-onset PD sample, which was closely matched in age to the post-mortem PD samples. The FDRI results suggest that disregulation of iron metabolism occurs in PD and that this disregulation may differ in earlier- versus later-onset PD, (C) 1999 Elsevier Science Inc.