A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers
A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers
复制标题
DOI：
10.1038/srep25170
复制
发表时间：
2016-04-27
影响因子：
4.6
通讯作者：
Chadeau-Hyam, Marc
中科院分区：
文献类型：
--
作者：
Castagne, Raphaele;Delpierre, Cyrille;Chadeau-Hyam, Marc
较低的社会经济地位（SEP）一直与健康状况较差。为了探索潜在的生物嵌入和SEP经历从生命早期到成年的后果，我们研究了SEP指标在整个生命过程中的不同点可能与28种炎症标志物的组合有关。使用来自欧洲癌症和营养前瞻性研究队列意大利部分的268名参与者的多重阵列测量的血液来源的炎症特征，我们评估了早期生活，年轻成年和成年后SEP与每个炎症标志物之间的关联，或者将它们组合成炎症评分。我们发现父亲从事体力劳动的参与者的炎症负担增加，通过增加CSF 3的血浆水平（G-CSF; β = 0.29; P = 0.002）和增加炎症评分（β = 1.96; P = 0.029）。社会流动性随后建模父亲的职业和最高的家庭职业之间的相互作用，揭示了一个显着的差异“稳定的非手动”的配置文件在生命过程中与“手动到非手动”的配置文件（β = 2.38，P = 0.023）。儿童期低SEP与成人炎症负担适度增加相关;然而，社会流动性分析表明，在生命过程中向上的社会流动性影响更大。
Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; beta = 0.29; P = 0.002), and an increased inflammatory score (beta = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father's occupation and the highest household occupation, revealing a significant difference between "stable Non-manual" profiles over the life course versus "Manual to Non-manual" profiles (beta = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course.