Influence of brain-derived neurotrophic factor and catechol O-methyl transferase polymorphisms on effects of meditation on plasma catecholamines and stress
Influence of brain-derived neurotrophic factor and catechol O-methyl transferase polymorphisms on effects of meditation on plasma catecholamines and stress
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DOI：
10.3109/10253890.2011.592880
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发表时间：
2012-01-01
影响因子：
2.3
通讯作者：
Kwon, Jun Soo
中科院分区：
文献类型：
--
作者：
Jung, Ye-Ha;Kang, Do-Hyung;Kwon, Jun Soo
基于脑源性神经营养因子（BDNF）和儿茶酚O-甲基转移酶（COMT）的遗传多态性，冥想可能会对压力和血浆儿茶酚胺产生不同的影响。80名定期练习冥想的成年人（40名男性，40名女性;平均年龄26岁）和57名健康对照成年人（35名男性，22名女性;平均年龄26岁）参加了研究。测量血浆儿茶酚胺（去甲肾上腺素（NE）、肾上腺素（E）和多巴胺（DA））浓度，并使用改良形式的应激反应量表。结果进行了分析，采用双因素协方差分析（ANCOVA）与控制和冥想科目，基因多态性作为因素，冥想持续时间作为协变量。双向ANCOVA显示，对照组和冥想组之间存在显著的相互作用，BDNF Val 66 Met多态性对DA/NE + DA/E（p = 0.042）和NE/E + NE/DA（p = 0.046）比值有显著影响。一个显着的相互作用，发现控制和冥想COMT Val 158 Met多态性和血浆NE浓度（p = 0.009）。冥想组中调整冥想持续时间的事后ANCOVA显示，COMT Met携带者的血浆NE浓度显著高于COMT瓦尔/瓦尔受试者（p = 0.025）。对照组和冥想组的BDNF瓦尔/Met基因型（p < 0.001）和BDNF Met/Met基因型（p = 0.003）的应激水平存在显著差异，而BDNF瓦尔/瓦尔基因型的应激水平在对照组和冥想组之间没有差异。这是第一个证据表明，根据BDNF或COMT多态性，冥想对血浆儿茶酚胺产生不同的影响。
Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Eighty adults (40 men, 40 women; mean age 26 years) who practiced meditation regularly and 57 healthy control adults (35 men, 22 women; mean age 26 years) participated. Plasma catecholamines (norepinephrine (NE), epinephrine (E), and dopamine (DA)) concentrations were measured, and a modified form of the Stress Response Inventory was administered. The results were analyzed using two-way analysis of covariance (ANCOVA) with control and meditation subjects, gene polymorphism as factors, and meditation duration as the covariate. Two-way ANCOVA showed a significant interaction between control and meditation subjects, and BDNF Val66Met polymorphism on DA/NE + DA/E (p = 0.042) and NE/E + NE/DA (p = 0.046) ratios. A significant interaction was found for control and meditation subjects with COMT Val158Met polymorphism and plasma NE concentrations (p = 0.009). Post hoc ANCOVA in the meditation group, adjusted for meditation duration, showed significantly higher plasma NE concentrations for COMT Met carriers than COMT Val/Val subjects (p = 0.025). Significant differences of stress levels were found between the control and meditation subjects in BDNF Val/Met (p < 0.001) and BDNF Met/Met (p = 0.003), whereas stress levels in the BDNF Val/Val genotype did not differ between the control and meditation groups. This is the first evidence that meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms.