Production of deuterium labelled (-)-epicatechin in a microreactor
Production of deuterium labelled (-)-epicatechin in a microreactor
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DOI：
10.1016/j.cej.2010.08.093
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发表时间：
2011-03-01
影响因子：
15.1
通讯作者：
Haswell, Stephen J.
中科院分区：
文献类型：
--
作者：
Betts, Jonathan W.;Kitney, Stuart P.;Haswell, Stephen J.
据报道，绿色茶儿茶素具有多种健康益处。为了了解它们在人体内的代谢和毒理学相互作用，需要使用稳定同位素标记的化合物进行研究，但它们可能耗时且昂贵。使用微反应器技术标记儿茶素可以更快地生产，并降低成本。本研究报道了一种利用微反应器技术两步合成氘标记表儿茶素的方法。(C)2010年爱思唯尔BM。All rights reserved.
Green tea catechins have been reported to have multiple health benefits. To understand their metabolic and toxicological interactions in the human body studies need to be undertaken using stable isotope labelled compounds, but they can be time consuming and expensive. Using microreactor technology labelling catechins could be produced more quickly and at a reduced cost. This research reports on a 2-step synthesis of deuterium labelled epicatechin developed using microreactor technology for the production. (C) 2010 Elsevier BM. All rights reserved.