Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses.
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses.
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DOI：
10.1631/jzus.b2000808
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发表时间：
2021-08-15
期刊：
影响因子：
--
通讯作者：
Yi H
中科院分区：
文献类型：
--
作者：
Chen Y;Lin J;Zhao Y;Ma X;Yi H
Toll样受体3(Toll-like Receptor 3，TLR3)是TLR家族的成员之一，介导I型干扰素(IFN)、促炎细胞因子和趋化因子的转录诱导，从而共同建立抗病毒宿主反应。研究表明，与其他TLR家族成员不同的是，TLR3是唯一完全依赖于Toll-IL-1受体(TIR)结构域的适配器诱导干扰素-β(TRIF)的RNA传感器。然而，TLR3-TRIF信号通路如何在抗病毒反应中发挥作用以及它是如何被调控的细节还不清楚。本文就TRIF途径抗病毒机制的最新研究进展作一综述，并介绍TLR3的基本特征及其抗病毒作用。提高我们对TLR3的理解可能有助于疾病的诊断，并可能促进病毒疾病的新疗法的开发。
Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response. Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)-domain-containing adaptor-inducing IFN-β (TRIF). However, the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear. In this review, we focus on recent advances in understanding the antiviral mechanism of the TRIF pathway and describe the essential characteristics of TLR3 and its antiviral effects. Advancing our understanding of TLR3 may contribute to disease diagnosis and could foster the development of novel treatments for viral diseases.
影响因子：
5.3
作者：
Nguyen VP;Chen J;Petrus MN;Goldman CK;Kruhlak MJ;Bamford RN;Waldmann TA
通讯作者：
Waldmann TA