Afferent pathways for cardiac-somatic motor reflexes in rats.
Afferent pathways for cardiac-somatic motor reflexes in rats.
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DOI：
10.1152/ajpregu.2001.281.6.r2096
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发表时间：
2001-12
期刊：
影响因子：
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通讯作者：
C. Jerry Jou;J. Farber;C. Qin;Robert D. Foreman
中科院分区：
文献类型：
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作者：
C. Jerry Jou;J. Farber;C. Qin;Robert D. Foreman
本研究采用大鼠模型，将致痛化学物质注入心包囊，引起椎旁肌痉挛样收缩。以下技术被用来研究交感神经（SCA）和迷走神经传入（VCA）的作用，在肌电图（EMG）的反应，心包致痛化学品：化学刺激，电刺激，神经切断。与缓激肽（n = 46）激活产生了显着更高的峰值响应比输液的algogenic混合物（n = 53）含有化学物质，也激活VCA。电刺激SCA产生双侧EMG活动（7/7）。电刺激VCA不引起EMG活动，但抑制化学诱发的EMG反应（12/12）。切断左侧交感神经链后，化学诱发反应降低（n = 22），双侧迷走神经切断后，增加（n = 19）。这些结果表明，兴奋和抑制作用SCA和VCA，分别。因此，除了躯体和内脏传入神经的脊髓丘脑会聚外，SCA激活产生痉挛样肌肉收缩可能是心绞痛的部分原因，VCA激活可以减弱这种作用。
The present study used a rat model in which algogenic chemicals were infused into the pericardial sac to evoke spasmlike contractions in paraspinal muscles. The following techniques were used to study the roles of sympathetic (SCA) and vagal cardiac afferents (VCA) in electromyographic (EMG) responses to pericardial algogenic chemicals: chemical stimulation, electrical stimulation, and nerve transection. Activation with bradykinin (n = 46) produced a significantly higher peak response than infusion of an algogenic mixture (n = 53) containing chemicals that also activate VCA. Electrical stimulation of SCA produced bilateral EMG activities (7 of 7). Electrical stimulation of VCA did not evoke EMG activity but inhibited the chemically evoked EMG response (12 of 12). The chemically evoked response was decreased after transection of the left sympathetic chain (n = 22) and was increased after bilateral vagotomy (n = 19). These results suggest an excitatory and inhibitory role for SCA and VCA, respectively. Therefore, in addition to spinothalamic convergence of somatic and visceral afferents, activation of SCA to generate spasmlike muscle contractions could account in part for anginal pain, and VCA activation could attenuate this effect.