Effects of excitotoxic lesions of the gustatory thalamus on latent inhibition and blocking of conditioned taste aversion in rats
Effects of excitotoxic lesions of the gustatory thalamus on latent inhibition and blocking of conditioned taste aversion in rats
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DOI：
10.1016/j.brainresbull.2003.08.009
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发表时间：
2003-12-15
影响因子：
3.8
通讯作者：
Trifunovic, R
中科院分区：
文献类型：
--
作者：
Reilly, S;Bornovalova, M;Trifunovic, R
在两个实验中检查了味觉丘脑的双侧兴奋性毒性损伤对条件性味觉厌恶（CTA）的潜在抑制和阻断的影响。在实验1中，大鼠丘脑病变表现出正常的潜伏抑制收购CTA是显着较弱的条件刺激（CS）时，熟悉的比当它是新的。在实验2中，化合物CS的预处理元素（氯化钠）阻断了正常大鼠对新元素（蔗糖）的CTA获取。无论氯化钠是否预处理，丘脑病变的大鼠表现出很少或没有厌恶蔗糖后复合空调。总体而言，研究结果没有提供支持的实验假设，丘脑病变破坏味觉刺激的注意力处理的递减变化。(C)2003爱思唯尔公司All rights reserved.
The influence of bilateral excitotoxic lesions of the gustatory thalamus on latent inhibition and blocking of conditioned taste aversion (CTA) was examined in two experiments. In Experiment 1, rats with thalamic lesions showed normal latent inhibition by acquiring a CTA that was significantly weaker when the conditioned stimulus (CS) was familiar than when it was novel. In Experiment 2, the preconditioned element (sodium chloride) of a compound CS blocked the acquisition of a CTA to the novel element (sucrose) in normal rats. Irrespective of whether sodium chloride was preconditioned or not, rats with thalamic lesions showed little or no aversion to sucrose following compound conditioning. Overall, the results provide no support for the experimental hypothesis that thalamic lesions disrupt decremental changes in the attentional processing of gustatory stimuli. (C) 2003 Elsevier Inc. All rights reserved.