Diastolic Dysfunction and Hypertension
Diastolic Dysfunction and Hypertension
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DOI：
10.1016/j.mcna.2016.08.013
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发表时间：
2017-01-01
影响因子：
5.9
通讯作者：
Solomon, Scott D.
中科院分区：
文献类型：
--
作者：
Nadruz, Wilson;Shah, Amil M.;Solomon, Scott D.
左室（LV）舒张功能障碍（LVDD）以左室舒张充盈改变为特征，是心血管事件和心力衰竭的重要预测指标。高血压是社会上LVDD最重要的危险因素，并通过血流动力学超载和心肌缺血等多种机制促进LVDD的发生。相关因素如年龄、种族、饮食钠、肥胖、糖尿病和慢性肾脏疾病也会导致高血压患者LVDD。降压药降压可改善LVDD；然而，左室舒张功能的改善是否能改善心血管预后尚不清楚。
Left ventricular (LV) diastolic dysfunction (LVDD) is characterized by alterations in LV diastolic filling, and is a strong predictor of cardiovascular events and heart failure. Hypertension is the most important risk factor for LVDD in the community and promotes LVDD through several mechanisms, including hemodynamic overload and myocardial ischemia. Associated factors such as age, ethnicity, dietary sodium, obesity, diabetes mellitus, and chronic kidney disease also contribute to LVDD in hypertensive individuals. Blood pressure lowering using antihypertensive medications can improve LVDD; however, it remains unclear whether this improvement in LV diastolic function can improve cardiovascular outcomes.