Parallel molecular evolution in an herbivore community.
Parallel molecular evolution in an herbivore community.
复制标题
DOI:
10.1126/science.1226630
复制
发表时间:
2012-09-28
期刊:
影响因子:
--
通讯作者:
Andolfatto P
中科院分区:
文献类型:
--
作者:
Zhen Y;Aardema ML;Medina EM;Schumer M;Andolfatto P
Numerous insects have independently evolved the ability to feed on plants that produce toxic secondary compounds called cardenolides and can sequester these compounds for use in their defense. We surveyed the protein target for cardenolides, the alpha subunit of the sodium pump, Na+,K+-ATPase (ATPα), in 14 species that feed on cardenolide-producing plants and 15 outgroups spanning three insect orders. Despite the large number of potential targets for modulating cardenolide sensitivity, amino acid substitutions associated with host-plant specialization are highly clustered, with many parallel substitutions. Additionally, we document four independent duplications of ATPα with convergent tissue-specific expression patterns. We find that unique substitutions are disproportionately associated with recent duplications relative to parallel substitutions. Together, these findings support the hypothesis that adaptation tends to take evolutionary paths that minimize negative pleiotropy.
登录
查看更多内容
影响因子:
4.5
作者:
De Pont, Jan Joep H. H. M.;Swarts, Herman G. P.;Koenderink, Jan B.
通讯作者:
Koenderink, Jan B.
影响因子:
4.9
作者:
Aardema, Matthew L.;Zhen, Ying;Andolfatto, Peter
通讯作者:
Andolfatto, Peter
DOI:
10.1016/0305-0491(93)90034-3
发表时间:
1993-12-01
影响因子:
2.2
作者:
ALROBAI, AA
通讯作者:
ALROBAI, AA
影响因子:
10.7
作者:
Labeyrie, E;Dobler, S
通讯作者:
Dobler, S
DOI:
10.1073/pnas.0907054106
发表时间:
2009-08-18
影响因子:
11.1
作者:
Ogawa, Haruo;Shinoda, Takehiro;Toyoshima, Chikashi
通讯作者:
Toyoshima, Chikashi