Sympathoadrenal stress reactivity is a predictor of future blood pressure - An 18-year follow-up study
Sympathoadrenal stress reactivity is a predictor of future blood pressure - An 18-year follow-up study
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DOI：
10.1161/hypertensionaha.108.111625
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发表时间：
2008-08-01
期刊：
影响因子：
8.3
通讯作者：
Rostrup, Morten
中科院分区：
文献类型：
--
作者：
Flaa, Arnljot;Eide, Ivar K.;Rostrup, Morten
在本研究中，我们假设在18年的随访中，静息和2次实验室负荷试验期间的动脉儿茶酚胺浓度是血压的独立预测因子。研究对象为99名健康男性（年龄：19.3 ± 0.4岁，平均值± SD），研究对象在入组时分别在静息状态、心算测试和冷加压测试中测量血压、心率、动脉血浆肾上腺素和去甲肾上腺素浓度。随访18.0 +/- 0.9年后，测量静息血压。在多元回归分析中，心算过程中的去甲肾上腺素和肾上腺素浓度解释了调整初始静息血压、家族史、体重指数和负荷试验期间收缩压后未来收缩压变化的12.7%（调整后R-2 = 0.651; P < 0.001）。总之，本研究表明，心算过程中的交感神经活动预测未来的血压，表明原发性高血压的发展独立于初始血压的一个可能的因果因素。
In the present study we hypothesized that arterial catecholamine concentrations during rest and 2 laboratory stress tests were independent predictors of blood pressure at an 18-year follow-up. At entry, blood pressure, heart rate, and arterial plasma epinephrine and norepinephrine concentrations were measured in 99 healthy men ( age: 19.3 +/- 0.4 years, mean +/- SD) at rest, during a mental arithmetic test, and during a cold pressor test. After 18.0 +/- 0.9 years of follow-up, resting blood pressure was measured. The norepinephrine and epinephrine concentrations during the mental arithmetic explained 12.7% of the variation of future systolic blood pressure after adjusting for initial resting blood pressure, family history, body mass index, and systolic blood pressure during the stress test in a multiple regression analysis ( adjusted R-2 = 0.651; P < 0.001). To conclude, the present study shows that sympathetic nervous activity during mental arithmetic predicts future blood pressure, indicating a possible causal factor in the development of essential hypertension independent of the initial blood pressure.