Immunological Consequences of Intestinal Fungal Dysbiosis.
Immunological Consequences of Intestinal Fungal Dysbiosis.
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肠道真菌失调的免疫学后果。
DOI：
10.1016/j.chom.2016.05.003
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发表时间：
2016-06-08
影响因子：
30.3
通讯作者：
Iliev ID
中科院分区：
文献类型：
--
作者：
Wheeler ML;Limon JJ;Bar AS;Leal CA;Gargus M;Tang J;Brown J;Funari VA;Wang HL;Crother TR;Arditi M;Underhill DM;Iliev ID
与细菌相比，人们对真菌在肠道微生物群中的作用知之甚少。在这项研究中，我们研究了肠道中“健康”真菌群落的存在是否对调节免疫功能很重要。小鼠长期口服抗真菌药物导致急性和慢性结肠炎模型的疾病严重程度增加，并且还加剧了过敏性气道疾病的发展。微生物群分析揭示了真菌和细菌群落的重组。具体来说，是念珠菌属的代表。减少，而曲霉属、壁球菌属和附球菌属。增加了。口服补充三种在抗真菌治疗期间会扩张的真菌（曲霉、黑曲霉和黑壁菌）的混合物足以重现抗真菌药物对过敏性气道疾病的加剧作用。综上所述，这些结果表明共生真菌种群的破坏可以影响局部和外周免疫反应并增强相关疾病状态。
Compared to bacteria, the role of fungi within the intestinal microbiota is poorly understood. In this study we investigated whether the presence of a “healthy” fungal community in the gut is important for modulating immune function. Prolonged oral treatment of mice with antifungal drugs resulted in increased disease severity in acute and chronic models of colitis, and also exacerbated the development of allergic airway disease. Microbiota profiling revealed restructuring of fungal and bacterial communities. Specifically, representation of Candida spp. was reduced, while Aspergillus, Wallemia, and Epicoccum spp. were increased. Oral supplementation with a mixture of three fungi found to expand during antifungal treatment (Aspergillus amstelodami, Epicoccum nigrum, and Wallemia sebi) was sufficient to recapitulate the exacerbating effects of antifungal drugs on allergic airway disease. Taken together these results indicate that disruption of commensal fungal populations can influence local and peripheral immune responses and enhance relevant disease states.