EFFECT OF ACUTE AND CHRONIC HYPERNATREMIA ON MYOINOSITOL AND SORBITOL CONCENTRATION IN RAT-BRAIN AND KIDNEY
EFFECT OF ACUTE AND CHRONIC HYPERNATREMIA ON MYOINOSITOL AND SORBITOL CONCENTRATION IN RAT-BRAIN AND KIDNEY
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DOI：
10.1016/0024-3205(88)90317-7
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
ACARA, M
中科院分区：
文献类型：
--
作者：
LOHR, JW;MCREYNOLDS, J;ACARA, M
在高钠血症的动物模型中，脑电解质含量的增加解释了急性高钠血症而非慢性高钠血症中渗透压的全部增加，表明在慢性高钠血症状态中产生了额外的细胞内溶质（“特发性渗透压摩尔浓度”）。本研究测定了腹腔注射氯化钠和水限制造成急性（2小时）和慢性（72小时）高钠血症大鼠脑和肾中多元醇肌醇和山梨醇的浓度及含水量。大脑和肾脏对慢性高钠血症的反应是肌醇水平升高。急性和慢性高钠血症时，肾脏中山梨醇水平均升高。水含量在急性高钠血症中下降，但在慢性高渗性挑战中保持不变。我们的结论是，多元醇，肌醇和山梨醇，可能在慢性高钠血症大鼠脑和肾细胞凋亡的调节中发挥重要作用。
In animal models of hypernatremia, increases in brain electrolyte content account for the entire increase in osmolality in acute but not chronic hypernatremia, suggesting that there is generation of additional intracellular solutes ("idiogenic osmoles") in chronic hypernatremic states. In the present study, the concentration of the polyols myoinositol and sorbitol and water content were determined in the brain and kidneys of rats made acutely (2 hours) and chronically (72 hours) hypernatremic by intraperitoneal injection of NaCl and water resriction. Both the brain and the kidney responded to chronic hypernatremia with increased levels of myoinositol. Sorbitol levels increased in the kidney in response to both acute and chronic hypernatremia. Water content dropped in acute hypernatremia, but remained unchanged during chronic hyperosmolar challenge. We conclude that the polyols, myoinositol and sorbitol, may play a significant role in cellular osmoregulation in brain and kidney during chronic hypernatremia in the rat.