SPATIOTEMPORAL MODELING OF CEREBRAL EVOKED MAGNETIC-FIELDS TO MEDIAN NERVE-STIMULATION
SPATIOTEMPORAL MODELING OF CEREBRAL EVOKED MAGNETIC-FIELDS TO MEDIAN NERVE-STIMULATION
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DOI：
10.1016/0013-4694(91)90153-u
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发表时间：
1991-07-01
期刊：
影响因子：
--
通讯作者：
BARTH, DS
中科院分区：
文献类型：
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作者：
BAUMGARTNER, C;SUTHERLING, WW;BARTH, DS
我们测量了6名正常人在正中神经刺激时的体感诱发磁场。 我们应用多个偶极子模型来研究早期体感诱发磁场（SEFs）的时空结构，以及其潜在的神经元源的数量，三维位置和时间活动。 两个偶极子源是必要的，以模拟前40毫秒的SEFs解释85%的数据方差。 源1比源2位于更深处，主要显示切线方向，并占方差的较大部分;源2显示受试者之间没有一致的方向。 两种来源均显示出对应于先前描述的N20-P30和P25-N35组分的双相时间活动。 时空建模可以识别的来源，不能被建模一致的噪声以上的单个移动偶极子（P25组件），揭示了小的延迟差异的两个来源在一些主题，这些来源的并行激活，并允许分离的源重叠相当大的空间和时间。 我们的结论是时空建模的SEFs可能是有用的研究人类感觉运动皮层的功能解剖非侵入性。
We measured somatosensory evoked magnetic fields during median nerve stimulation in 6 normal subjects. We applied multiple dipole models to study the spatiotemporal structure of early somatosensory evoked magnetic fields (SEFs), as well as the number, 3-dimensional location and time activity of their underlying neuronal sources. Two dipole sources were necessary to model the first 40 msec of SEFs explaining 85% of the data variance. Source 1 was located deeper than source 2, showed primarily a tangential orientation, and accounted for a larger part of the variance; source 2 showed no consistent orientation across subjects. Both sources showed biphasic time activities corresponding to the previously described N20-P30 and P25-N35 components. Spatiotemporal modeling could identify sources which could not be modeled consistently above noise by single moving dipoles (P25 component), revealed small latency differences of the two sources in some subjects suggesting parallel activation of these sources, and allowed separation of sources overlapping considerably both in space and time. We conclude that spatiotemporal modeling of SEFs may be useful to study functional anatomy of human sensorimotor cortex non-invasively.