TREATMENT OF MALIGNANT NEOPLASMS OF GASTROINTESTINAL TRACT WITH A COMBINATION OF 5-FLUOROURACIL AND RADIATION - A RANDOMIZED DOUBLE-BLIND STUDY
TREATMENT OF MALIGNANT NEOPLASMS OF GASTROINTESTINAL TRACT WITH A COMBINATION OF 5-FLUOROURACIL AND RADIATION - A RANDOMIZED DOUBLE-BLIND STUDY
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DOI：
10.1148/84.5.843
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发表时间：
1965-01-01
期刊：
影响因子：
19.7
通讯作者：
COLBY, MY
中科院分区：
文献类型：
--
作者：
CHILDS, DS;MOERTEL, CG;COLBY, MY
本研究旨在比较单独放疗以及联合放疗和 5-氟尿嘧啶 (5-FU) 治疗胃肠癌的临床结果。不考虑单独给予 5-FU 或根本不给予治疗的可能结果。没有尝试确定联合治疗的结果增强是否是由于协同作用、累加效应、治疗比的改善等。在分配化疗加放疗或不化疗但单独放疗时采用了随机化过程。可能影响结果的其他评估变量包括：年龄、性别、第 1 组和第 2 组中病变的局部范围（由 Dukes 分类表示）、病变的组织学分级（Broders 方法）、病变范围是通过手术探查还是临床检查确定，以及病变是原发性还是复发性。需要强调的是，这些结论仅适用于所研究的疾病类型、所施用的辐射剂量以及所采用的 5-FU 的剂量和剂量方案。
This study was designed to compare the clinical results of treatment with radiation alone and with combined radiation and 5-fluorouracil (5-FU) in gastrointestinal cancer. The possible results if 5-FU alone were administered or if no treatment at all were given were not considered. No attempt was made to determine whether any enhancement of results from combined therapy would be due to synergism, additive effect, improvement in the therapeutic ratio, etc. A process of randomization was used in assigning chemotherapy in addition to radiation or no chemotherapy but radiation alone. Other variables assessed which might have influenced results were: age, sex, local extent of the lesion (denoted by Dukes'' classification) in Groups 1 and 2, histologic grade of the lesion (Broders'' method), whether the extent of the lesion was determined by surgical exploration or clinical examination, and whether the lesion was primary or recurrent. It is emphasized that the conclusions apply only to the type of disease studied, to the dose of radiation administered, and to the dose and dosage schedule of 5-FU employed.