Detection of Active Sacroiliitis with Ankylosing Spondylitis through Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging
Detection of Active Sacroiliitis with Ankylosing Spondylitis through Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging
复制标题
通过体素内不相干运动扩散加权磁共振成像检测活动性骶髂关节炎和强直性脊柱炎
DOI：
10.1007/s00330-015-3634-2
复制
发表时间：
2015-09-01
影响因子：
5.9
通讯作者：
Liang, Chang-hong
中科院分区：
文献类型：
--
作者：
Zhao, Ying-hua;Li, Shao-lin;Liang, Chang-hong
Objectives To confirm feasibility and assess intravoxel incoherent motion (IVIM) to differentiate active sacroiliitis and ankylosing spondylitis..Methods Forty-one patients were divided into two groups, an active group (n = 20) and a chronic group (n = 21), according to the Bath Ankylosing Spondylitis (AS) Disease Activity Index (BASDAI) and laboratory parameters. In addition, 21 healthy volunteers were chosen as the control group. Tissue diffusivity (D-slow), perfusion fraction (f), and pseudo-diffusion coefficient (D-fast) values were obtained for all three groups. One-way analysis of variance and receiver operating characteristic analysis were performed for all parameters.Results There was good interobserver agreement on the measurements between the two observers. The optimal cut-off values (with respective AUC, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio) between active and chronic groups were D-slow = 0.53 x 10(-3) mm(2)/s (0.976, 90 %, 95.2 %, 18.9, 0.10) and f = 0.09 (0.545, 20 %, 95.5 %, 4.2, 0.84), and between chronic and control groups were D-slow = 0.22 x 10(-3) mm(2)/s (0.517, 9.52 %, 100 %, no number, 0.9) and f = 0.09 (0.935, 95.24 %, 80.95 %, 5, 0.059).Conclusions D-slow and f of IVIM diffusion-weighted (DW)-MRI in AS show a significant difference in the values of diffusion of water molecules and fractional perfusion-related volume among the three groups.
