The embryonic development of the inferior olivary complex in normal and reeler (rlORL) mutant mice
The embryonic development of the inferior olivary complex in normal and reeler (rlORL) mutant mice
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正常和 reeler (rlORL) 突变小鼠下橄榄复合体的胚胎发育
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
A. Goffinet
中科院分区：
文献类型：
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作者：
A. Goffinet
在正常小鼠和 reeler 突变小鼠中，从胚胎第 14 天到出生，对下橄榄复合体的发育进行了比较研究。在这两种基因型中，细胞从第四脑室的侧隐窝切向迁移，直到它们到达腹侧菱脑，在那里它们径向进入橄榄。有些细胞还从橄榄的外侧横向进入橄榄。在这两种基因型中，橄榄神经元在树突部署和轴突生长方面都遵循相同的形态序列分化。橄榄轴突早在 E14 就穿过中线。在产前时期，下橄榄复合体中的突触很少见。两种基因型中的放射状胶质细胞和星形胶质细胞发生的第一阶段看起来相似。
The development of the inferior olivary complex has been studied comparatively in normal and reeler mutant mice, from embryonic day 14 to birth. In both genotypes, cells migrate tangentially, from the lateral recess of the fourth ventricle, until they reach the ventral rhombencephalon where they enter the olive radially. Some cells also enter the olive laterally, from its external side. In both genotypes, olivary neurons differentiate following the same morphological sequence, both in terms of dendritic deployment and of axonal growth. Olivofugal axons cross the midline as early as E14. Synapses are rare in the inferior olivary complex during the prenatal period. Radial glial cells and the first stages of astrocytogenesis appear similar in both genotypes.