Hypertriglyceridemia is associated with development of metabolic glucose disorders, irrespective of glucose and insulin levels: A 15-year follow-up study
Hypertriglyceridemia is associated with development of metabolic glucose disorders, irrespective of glucose and insulin levels: A 15-year follow-up study
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DOI：
10.1016/j.ejim.2014.01.015
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发表时间：
2014-03-01
影响因子：
8
通讯作者：
Rodriguez-Moran, Martha
中科院分区：
文献类型：
--
作者：
Guerrero-Romero, Fernando;Rodriguez-Moran, Martha
背景：由于负荷后2小时葡萄糖和胰岛素水平作为混杂因素在高甘油三酯血症和代谢性葡萄糖疾病（MGD）发展之间的关系中的作用尚未阐明，本研究的目的是确定甘油三酯水平>= 1.7 mmol/L是否是健康男性和女性发生MGD的危险因素。方法：共有341名30至50岁的健康男性和未怀孕女性参加了一项为期15年的随访研究，并将其分为暴露组（甘油三酯>= 1.7 mmol/L）和未暴露组（甘油三酯= 1.7 mmol/L）和IFG组（相对风险- RR - 1.40; 95% CI 1.2-2.2）、IGT组（RR 1.60; 95% CI 1.3-2.2）、IFG + IGT组（RR 1.80; 95% CI 1.5-2.7）和2型糖尿病组（RR 3.0; 95% CI 2.5-3.8）。结论：血清甘油三酯水平>= 1.7 mmol/L是中青年、男性和女性发生IFG、IGT、IFG + IGT和2型糖尿病的独立危险因素。(C) 2014年欧洲内科联合会。Elsevier b.v.版权所有。
Background: Because the role of 2-h postload glucose and insulin levels as confounders in the relationship between hypertriglyceridemia and development of metabolic glucose disorders (MGD) has not been elucidated, the aim of this study was to determine whether triglyceride levels >= 1.7 mmol/L are a risk factor of developing MGD in otherwise healthy men and women.Methods: A total of 341 healthy men and non-pregnant women, 30 to 50 years of age, were enrolled in a 15-year follow-up study and allocated into the exposed (triglycerides >= 1.7 mmol/L) and non-exposed (triglycerides = 1.7 mmol/L and IFG (relative risk - RR - 1.40; 95% CI 1.2-2.2), IGT (RR 1.60; 95% CI 1.3-2.2), IFG + IGT (RR 1.80; 95% CI 1.5-2.7), and type 2 diabetes (RR 3.0; 95% CI 2.5-3.8).Conclusions: Serum triglyceride levels >= 1.7 mmol/L are an independent risk factor of developing IFG, IGT, IFG + IGT, and type 2 diabetes in young and middle-aged, men and women. (C) 2014 European Federation of Internal Medicine. Published by Elsevier B. V. All rights reserved.