An RCT to treat learning impairment in multiple sclerosis The MEMREHAB trial
An RCT to treat learning impairment in multiple sclerosis The MEMREHAB trial
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DOI：
10.1212/01.wnl.0000437295.97946.a8
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发表时间：
2013-12-10
期刊：
影响因子：
9.9
通讯作者：
DeLuca, John
中科院分区：
文献类型：
--
作者：
Chiaravalloti, Nancy D.;Moore, Nancy B.;DeLuca, John
目的：研究改良的故事记忆技术（mSMT），一种10次行为干预教学背景和图像，以促进学习，改善多发性硬化症（MS）患者的学习和记忆能力的有效性。这项双盲、安慰剂对照、随机临床试验包括86名临床确诊MS的参与者，其中41名在治疗组，45名在安慰剂对照组。参与者完成了基线神经心理学评估，包括评估日常记忆的问卷调查，治疗后立即重复评估，以及治疗后6个月的长期随访评估。治疗阶段完成后，在治疗组的人被分配到一个助推器会议或非助推器会议组检查每月助推器会议的疗效，促进治疗效果随着时间的推移。结果：治疗组表现出显着改善学习斜率相对于安慰剂组posttreatment。在日常记忆、总体满意度以及家庭报告的冷漠和执行功能障碍的客观测量中也观察到了类似的结果。长期随访数据显示，治疗组的治疗后改善继续在列表学习和自我报告的措施。助推器会议的提供表现出一点benefit.Conclusion：mSMT是有效的改善MS的学习和记忆。证据分类：本研究提供了I类证据表明，mSMT行为干预改善MS患者的客观记忆和日常记忆超过5周，治疗效果持续超过6个月。
Objective: To examine the efficacy of the modified Story Memory Technique (mSMT), a 10-session behavioral intervention teaching context and imagery to facilitate learning, to improve learning and memory abilities in persons with multiple sclerosis (MS).Methods: This double-blind, placebo-controlled, randomized clinical trial included 86 participants with clinically definite MS, 41 in the treatment group and 45 in the placebo control group. Participants completed a baseline neuropsychological assessment, including questionnaires assessing everyday memory, a repeat assessment immediately posttreatment, and a long-term follow-up assessment 6 months after treatment. After completion of the treatment phase, persons in the treatment group were assigned to a booster session or a non-booster session group to examine the efficacy of monthly booster sessions in facilitating the treatment effect over time.Results: The treatment group showed a significantly improved learning slope relative to the placebo group posttreatment. Similar results were noted on objective measures of everyday memory, general contentment, and family report of apathy and executive dysfunction. Long-term follow-up data showed that posttreatment improvement in the treatment group continued to be noted on the list learning and self-report measures. The provision of booster sessions demonstrated little benefit.Conclusion: The mSMT is effective for improving learning and memory in MS. Classification of evidence: This study provides Class I evidence that the mSMT behavioral intervention improves both objective memory and everyday memory in patients with MS over 5 weeks, with treatment effects lasting over a 6-month period.