THE STRUCTURE OF FIBROUS PROTEINS OF THE COLLAGEN-GELATIN GROUP
THE STRUCTURE OF FIBROUS PROTEINS OF THE COLLAGEN-GELATIN GROUP
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DOI：
10.1073/pnas.37.5.272
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发表时间：
1951-01-01
影响因子：
11.1
通讯作者：
COREY, RB
中科院分区：
文献类型：
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作者：
PAULING, L;COREY, RB
图1胶原蛋白三链螺旋中多肽链构型的图示。单独的顺式酰胺基团。然而，如图1和图2所示，使用两个顺式基团和一个反式基团交替的多肽链，已经配制出了在以下段落中详细描述的令人满意的结构。反式基团通过其与相邻顺式基团的键而需要呈现的角取向使得其沿纤维轴的长度分量沿着为约2.92埃，因此顺-顺-反链的每个残基的平均纤维轴长度为2.86埃，如对胶原纤维所观察到的。现在让我们考虑顺-顺-反链的折叠，使之形成令人满意的氢键。外侧肿胀的容易程度
FIGURE 1 Diagrammatic representation of the configuration of polypeptide chains in the collagengelatin three-chain helix. from cis amide groups alone. However, a satisfactory structure, described in detail in the following paragraphs, has been formulated with use of poly-peptide chains in which there is an alternation of two cis groups andone trans group, as shown in figures 1 and 2. The angular orientation which the trans group is required to assume by its bonds with the contiguous cis groups is such as to cause its component of length along the fiber axis to be about 2.92 A, the average fiber-axis length per residue for the cis-cis-trans chain thus being 2.86 A, as observed for the collagen fibers. Let us now consider the folding of the cis-cis-trans chain in such a way as to form satisfactory hydrogen bonds. The ease of lateral swelling of