Concepts and mechanisms of generalized central nervous system arousal
Concepts and mechanisms of generalized central nervous system arousal
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DOI：
10.1196/annals.1417.019
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Kow, Lee-Ming
中科院分区：
文献类型：
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作者：
Pfaff, Donald;Ribeiro, Ana;Kow, Lee-Ming
提出了中枢神经系统广义觉醒的概念，并给出了导致量化物理测量的可操作性定义。因为这种原始的唤醒功能是所有动机行为反应、认知功能和情感表达的基础，所以广泛性唤醒障碍可能与医学和公共卫生中的大量问题有关，包括植物人状态、注意力障碍、抑郁症、职业危害以及睡眠和麻醉问题。在神经解剖学、神经生理学和功能基因组学水平上，对其一些已知的机制进行了简要回顾。在特定的唤醒状态下，广泛性唤醒有助于行为的兴奋和激活。总结了四个基因组/神经化学系统的数据，通过这些系统，广义唤醒的变化可以影响性唤醒，其中两个系统增强，另外两个系统降低唤醒。
A concept of generalized arousal of the CNS is presented and given an operational definition that leads to quantitative physical measures. Because this primitive arousal function underlies all motivated behavioral responses, cognitive functions, and emotional expression, disorders of generalized arousal can be associated with a large number of problems in medicine and public health, including vegetative states, attentional disorders, depression, occupational hazards, and problems with sleep and anesthesia. Some of its known mechanisms are briefly reviewed, at the levels of neuroanatomy, neurophysiology, and functional genomics. Generalized arousal contributes to the excitement and the activation of behaviors during specific arousal states. Data are summarized for four genomic/neurochemical systems through which changes in generalized arousal could affect sexual arousal, two of which heighten, and the other two of which reduce arousal.