THE CREATINE-KINASE SYSTEM IN NORMAL AND DISEASED HUMAN MYOCARDIUM
THE CREATINE-KINASE SYSTEM IN NORMAL AND DISEASED HUMAN MYOCARDIUM
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DOI：
10.1056/nejm198510243131704
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
ALLEN, PD
中科院分区：
文献类型：
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作者：
INGWALL, JS;KRAMER, MF;ALLEN, PD
我们测量了来自四组的34名成年人的左心室心肌活检样品中的肌酸激酶活性，同工酶组成和总肌酸样品中的肌酸总含量：患有正常左心室的受试者，由于主动脉瓣狭窄而导致的左心室肥大患者，没有冠状动脉疾病，没有冠状动脉疾病左心室肥大，患有冠状动脉疾病的患者和由于主动脉狭窄引起的左心室肥大。与正常左心室的标本相比，所有左心室肥大患者的肌酸激酶活性较低，MB肌酸激酶同工酶含量和活性较高，肌酸含量较低。没有左心室肥大的患者的标本具有正常的肌酸激酶活性，增加了MB肌酸激酶同工酶含量和活性，并减少了总肌酸。正常的心室几乎没有MB同工酶含量或活性。这些数据表明，肌酸激酶系统的变化发生在压力超负荷肥大和冠状动脉疾病中。心肌梗死患者患有轻度或没有固定冠状动脉疾病或压力超负荷肥大的患者不会升高血清MB MB肌酸激酶。
We measured creatine kinase activity, isozyme composition, and total creatine content in biopsy samples of left ventricular myocardium from 34 adults in the four groups: subjects with normal left ventricles, patients with left ventricular hypertrophy due to aortic stenosis, patients with coronary artery disease without left ventricular hypertrophy, and patients with coronary artery disease and left ventricular hypertrophy due to aortic stenosis. As compared with specimens of normal left ventricles, those from all patients with left ventricular hypertrophy had lower creatine kinase activity, higher MB creatine kinase isozyme content and activity, and lower creatine content. Specimens from the patients without left ventricular hypertrophy had normal creatine kinase activity, increased MB creatine kinase isozyme content and activity, and decreased total creatine content. The normal ventricles showed almost no MB isozyme content or activity. These data suggest that changes in the creatine kinase system occur in both pressure-overload hypertrophy and coronary artery disease. Patients with myocardial infarction who have mild or no preexisting fixed coronary artery disease or pressure-overload hypertrophy would not be expected to have elevation of serum MB creatine kinase.