TRIAL OF MINOCYCLINE GIVEN AFTER EXPOSURE TO PREVENT GONORRHEA
TRIAL OF MINOCYCLINE GIVEN AFTER EXPOSURE TO PREVENT GONORRHEA
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DOI：
10.1056/nejm197905103001903
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
HOLMES, KK
中科院分区：
文献类型：
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作者：
HARRISON, WO;HOOPER, RR;HOLMES, KK
在一项对淋病抗生素预防的前瞻性评价中，1080名男性在远东港口与妓女性交后口服200 mg米诺环素或安慰剂。后来，在海上，565名服用安慰剂的男性中有57人检测到淋球菌感染，515名服用米诺环素的男性中有24人检测到淋球菌感染（P < 0.001）。米诺环素预防完全防止了对0.75 μ g或更少四环素/ml敏感的淋球菌的感染，降低了感染的危险或延长了暴露于对1.0-2.0 μ g/ml敏感的淋球菌的男性的潜伏期，但不能防止感染或延长暴露于对2.0 μ g/ml耐药的淋球菌的男性的潜伏期。米诺环素未增加无症状感染者比例。米诺环素预防作为一种公共卫生措施可能效果有限，因为倾向于选择耐药淋球菌。
In a prospective evaluation of antibiotic prophylaxis against gonorrhea, 1080 men were given 200 mg of oral minocycline or placebo after sexual intercourse with prostitutes in a Far Eastern port. Later, at sea, gonococcal infection was detected in 57 of 565 men given placebo and 24 of 515 men given minocycline (P < 0.001). Minocycline prophylaxis completely prevented infection by gonococci susceptible to 0.75 .mu.g or less of tetracycline/ml, reduced the risk of infection or prolonged the incubation period in men exposed to gonococci susceptible to 1.0-2.0 .mu.g/ml, but did not prevent infection or prolong incubation in men exposed to gonococci resistant to 2.0 .mu.g. Minocycline did not increase the proportion of asymptomatic infections. Minocycline prophylaxis would probably have limited effectiveness as a public health measure because of the tendency to select resistant gonococci.