Effect of Cocaine on the Disposition of Noradrenaline labelled with Tritium
Effect of Cocaine on the Disposition of Noradrenaline labelled with Tritium
复制标题
可卡因对氚标记去甲肾上腺素处置的影响
DOI：
10.1038/187604a0
复制
发表时间：
1960
期刊：
影响因子：
64.8
通讯作者：
Julius Axelrod
中科院分区：
文献类型：
--
作者：
L. G. Whitby;L. G. Whitby;G. Hertting;Julius Axelrod
可卡因增强交感神经支配的器官对肾上腺素、去甲肾上腺素和交感神经刺激的反应，并对此提出了几种解释。卡农和罗森布鲁特认为，可卡因可能通过阻止注射的肾上腺素或从肾上腺素能神经释放的递质物质的破坏来发挥作用，托达2和特伦堡3获得了支持这一假说的证据。麦克米伦提出，可卡因可能会阻止儿茶酚胺进入组织存储，并阻止它们从这些存储中释放，但他的证据只是间接的。
COCAINE potentiates the responses of sympathetically innervated organs to adrenaline, noradrenaline and sympathetic nerve stimulation, and several explanations have been offered for this. Cannon and Rosenblueth1 suggested that cocaine might act by preventing the destruction of injected adrenaline, or of transmitter substance released from adrenergic nerves, and Torda2 and Trendelenburg3 obtained evidence in support of this hypothesis. Macmillan4 suggested that cocaine might prevent the uptake of catecholamines into tissue stores, and block their release from these stores, but his evidence was only indirect.