MALNUTRITION, CELL-MEDIATED IMMUNE-DEFICIENCY, AND DIARRHEA - A COMMUNITY-BASED LONGITUDINAL-STUDY IN RURAL BANGLADESHI CHILDREN
MALNUTRITION, CELL-MEDIATED IMMUNE-DEFICIENCY, AND DIARRHEA - A COMMUNITY-BASED LONGITUDINAL-STUDY IN RURAL BANGLADESHI CHILDREN
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DOI：
10.1093/oxfordjournals.aje.a116682
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发表时间：
1993-02-01
影响因子：
5
通讯作者：
SIDDIQUE, AK
中科院分区：
文献类型：
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作者：
BAQUI, AH;BLACK, RE;SIDDIQUE, AK
一项以社区为基础的纵向研究在孟加拉的农村地区MatLab进行。1988年5月至4月，研究了营养不良、细胞免疫缺陷和5岁以下儿童腹泻发病率之间的关系。对705名儿童进行了为期一年的跟踪调查；每隔四天通过家访确定疾病，每月评估人体测量状态，并在基线和每三个月通过多抗原皮肤试验评估细胞介导的免疫状态。腹泻发病率为4.6次/年。大约四分之三的儿童年龄体重低于-2z，身高低于-2z，约三分之一的儿童身高低于-2z。营养不良和腹泻发病率之间存在适度的关联。大约10%-20%的研究儿童患有无能，与免疫能力强的儿童相比，这些儿童的腹泻发病率增加了50%。在控制了年龄、营养状况、社会经济状况和前3个月的腹泻病史的影响后，这种关联仍然存在。营养不良和细胞免疫缺陷是腹泻发生的重要独立危险因素，在设计控制这种情况的干预措施时必须同时考虑这两个因素。
A community-based longitudinal study was conducted in Matlab, a rural area of Bangladesh. from May 1988 to April 1989 to examine the associations among malnutrition, cell-mediated immune deficiency, and the incidence of diarrhea in children under age 5 years. A cohort of 705 children was followed for a year; illnesses were ascertained every fourth day by home visits, anthropometric status was evaluated monthly, and cell-mediated immune status was assessed by a multiple antigen skin test at baseline and every 3 months. The diarrhea incidence rate was 4.6 episodes per year. Approximately three quarters of the children were below -2 z score weight for age and height for age, and about a third were below -2 z score weight for height. There was a modest association between undernutrition and the incidence of diarrhea. About 10-20% of the study children were anergic, and these children experienced a 50% increased incidence of diarrhea compared with their immunocompetent counterparts. This association persisted after controlling for the effects of age, nutritional status, socioeconomic status, and history of diarrhea in the previous 3 momths. Malnutrition and cell-mediated immune deficiency were important independent risk factors for the occurrence of diarrhea and must both be considered in the design of interventions for the control of this condition.