Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats.
Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats.
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DOI：
10.1515/jcim-2013-0022
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发表时间：
2014-06-01
影响因子：
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通讯作者：
Sahebkar, Amirhossein
中科院分区：
文献类型：
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作者：
Asgary, Sedigheh;Rafieian-Kopaei, Mahmoud;Sahebkar, Amirhossein
背景：花色苷是一种具有抗糖尿病、降血脂等多种药理作用的植物化学物质。本研究旨在评价山茱萸（Cornus mas L.，方法：将28只成年雄性大鼠随机分为4组，每组7只动物：非糖尿病对照组、糖尿病对照组、格列本脲治疗组（0.6 mg/kg/d; 4周）和CM水果治疗组（2 g/d; 4周）。通过单次注射四氧嘧啶（120 mg/kg）诱导糖尿病。于研究结束时检测空腹血糖、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、谷草转氨酶（AST）、谷丙转氨酶（ALT）和碱性磷酸酶（ALP）水平。与非糖尿病组相比，糖尿病组大鼠血糖、LDL-C、TG、AST、ALP、ALT水平显著升高，HDL-C水平显著降低（p
BACKGROUND: Anthocyanins are phytochemicals with a multitude of pharmacological actions including anti-diabetic and anti-hyperlipidemic effects. This study was undertaken to evaluate the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L., CM) fruits - that are rich in anthocyanins and known to have medicinal properties- in alloxan-induced diabetic rats.METHODS: Twenty-eight adult male rats were randomly assigned to four groups of seven animals each: non-diabetic control, diabetic control, glibenclamide-treated (0.6 mg/kg/day; 4 weeks) and CM fruit-treated (2 g/day; 4 weeks) group. Diabetes was induced by a single injection of alloxan (120 mg/kg). Fasting serum levels of glucose, total cholesterol (TC), low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), aspartate (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured at the end of study period.RESULTS: Diabetic rats had significantly elevated levels of serum glucose, LDL-C, TG, AST, ALP and ALT and decreased levels of HDL-C compared to the non-diabetic group (p