Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants.
Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants.
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DOI：
10.3390/vaccines3030620
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发表时间：
2015-08-05
期刊：
影响因子：
7.8
通讯作者：
Lamarre A
中科院分区：
文献类型：
--
作者：
Lebel MÈ;Chartrand K;Leclerc D;Lamarre A
疫苗被认为是对抗传染病的最伟大的医学成就之一。然而，由于传统的疫苗开发方法已被证明是无效的，各种疾病如丙型肝炎、艾滋病毒/艾滋病、疟疾、结核病和癌症的棘手性构成了持续的障碍;因此，这些挑战推动了新型疫苗设计方法的出现。在这方面，已投入大量努力开发新的安全佐剂和疫苗平台。特别令人感兴趣的是，植物病毒样纳米颗粒和重组植物病毒的利用作为开发针对传染病和癌症的新型疫苗的有效工具已经获得了越来越重要的意义。本文综述了近年来植物病毒作为纳米疫苗和佐剂的研究进展及其作用机制。利用植物病毒的免疫原性特性将能够设计新颖、安全和有效的疾病预防和治疗疫苗。
Vaccines are considered one of the greatest medical achievements in the battle against infectious diseases. However, the intractability of various diseases such as hepatitis C, HIV/AIDS, malaria, tuberculosis, and cancer poses persistent hurdles given that traditional vaccine-development methods have proven to be ineffective; as such, these challenges have driven the emergence of novel vaccine design approaches. In this regard, much effort has been put into the development of new safe adjuvants and vaccine platforms. Of particular interest, the utilization of plant virus-like nanoparticles and recombinant plant viruses has gained increasing significance as an effective tool in the development of novel vaccines against infectious diseases and cancer. The present review summarizes recent advances in the use of plant viruses as nanoparticle-based vaccines and adjuvants and their mechanism of action. Harnessing plant-virus immunogenic properties will enable the design of novel, safe, and efficacious prophylactic and therapeutic vaccines against disease.