The Mycobacterium tuberculosis Sigma Factor σB Is Required for Full Response to Cell Envelope Stress and Hypoxia In Vitro, but It Is Dispensable for In Vivo Growth
The Mycobacterium tuberculosis Sigma Factor σB Is Required for Full Response to Cell Envelope Stress and Hypoxia In Vitro, but It Is Dispensable for In Vivo Growth
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DOI：
10.1128/jb.00510-09
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发表时间：
2009-09-15
影响因子：
3.2
通讯作者：
Smith, I.
中科院分区：
文献类型：
--
作者：
Fontan, P. A.;Voskuil, M. I.;Smith, I.
结核分枝杆菌中存在的众多sigma （sigma）因子表明这种病原体对不同环境条件的适应性。在本报告中，我们描述了结核分枝杆菌sigma(B)调控和结核分枝杆菌sigB突变株暴露于包膜应激、氧化应激和缺氧的表型。sigB突变体在体外缺氧条件下的生存能力特别差，但在THP-1细胞中生长或小鼠和豚鼠感染期间，它没有减弱。
The numerous sigma (sigma) factors present in Mycobacterium tuberculosis are indicative of the adaptability of this pathogen to different environmental conditions. In this report, we describe the M. tuberculosis sigma(B) regulon and the phenotypes of an M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia. The sigB mutant was especially defective in survival under hypoxic conditions in vitro, but it was not attenuated for growth in THP-1 cells or during mouse and guinea pig infection.